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Mind the gap! Steric-driven reductive desymmetrisation of malononitriles

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dc.contributor.authorPhilipson, Cara
dc.contributor.authorHoogesteger, Reece H.
dc.contributor.authorJohnston, Craig P.
dc.date.accessioned2025-02-17T10:30:11Z
dc.date.available2025-02-17T10:30:11Z
dc.date.issued2025-02-12
dc.identifier312912717
dc.identifierbfd519ce-d137-40ed-877e-6a67b830370d
dc.identifier85213574005
dc.identifier.citationPhilipson , C , Hoogesteger , R H & Johnston , C P 2025 , ' Mind the gap! Steric-driven reductive desymmetrisation of malononitriles ' , Trends in Chemistry , vol. 7 , no. 2 , pp. 59-61 . https://doi.org/10.1016/j.trechm.2024.12.002en
dc.identifier.issn2589-7209
dc.identifier.otherRIS: urn:44F8C4A00BDC5BF44552956B191C8F50
dc.identifier.otherORCID: /0000-0003-2459-1872/work/175528807
dc.identifier.urihttps://hdl.handle.net/10023/31393
dc.descriptionFunding: The authors acknowledge financial support from Syngenta, EPSRC (EP/X013081/1) and The Royal Society (University Research Fellowship URF\R1\180017, URF\R\231016, and associated Enhancement Award RGF\EA\181022).en
dc.description.abstractHuang and coworkers recently demonstrated that a cobalt(I)-hydride complex, ligated with a finely tuned chiral bisoxazoline ligand, can selectively reduce disubstituted malononitriles by discriminating between enantiotopic nitrile groups. This reductive desymmetrisation strategy utilises the bulk industrial feedstock malononitrile to access nitrogen-rich enantioenriched products.
dc.format.extent3
dc.format.extent748106
dc.language.isoeng
dc.relation.ispartofTrends in Chemistryen
dc.rights© 2024 The Author(s). This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectEnantioselectiveen
dc.subjectDesymmetrisationen
dc.subjectCobalten
dc.subjectReductionen
dc.subjectMalononitrileen
dc.subjectQD Chemistryen
dc.subjectT-NDASen
dc.subjectMCCen
dc.subject.lccQDen
dc.titleMind the gap! Steric-driven reductive desymmetrisation of malononitrilesen
dc.typeJournal articleen
dc.contributor.sponsorThe Royal Societyen
dc.contributor.sponsorThe Royal Societyen
dc.contributor.sponsorThe Royal Societyen
dc.contributor.sponsorEPSRCen
dc.contributor.institutionUniversity of St Andrews.School of Chemistryen
dc.identifier.doi10.1016/j.trechm.2024.12.002
dc.description.statusPeer revieweden
dc.identifier.grantnumberURF\R\231016en
dc.identifier.grantnumberURF/R1/180017en
dc.identifier.grantnumberRGF\EA\181022en
dc.identifier.grantnumberEP/X013081/1en


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