Mind the gap! Steric-driven reductive desymmetrisation of malononitriles

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Date
12/02/2025
Author
Funder
Grant ID
URF\R\231016
URF/R1/180017
RGF\EA\181022
EP/X013081/1
Keywords
MCC
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Abstract
Huang and coworkers recently demonstrated that a cobalt(I)-hydride complex, ligated with a finely tuned chiral bisoxazoline ligand, can selectively reduce disubstituted malononitriles by discriminating between enantiotopic nitrile groups. This reductive desymmetrisation strategy utilises the bulk industrial feedstock malononitrile to access nitrogen-rich enantioenriched products.
Citation
Philipson , C , Hoogesteger , R H & Johnston , C P 2025 , ' Mind the gap! Steric-driven reductive desymmetrisation of malononitriles ' , Trends in Chemistry , vol. 7 , no. 2 , pp. 59-61 . https://doi.org/10.1016/j.trechm.2024.12.002
Publication
Trends in Chemistry
Status
Peer reviewed
DOI
https://doi.org/10.1016/j.trechm.2024.12.002
ISSN
2589-7209
Type
Journal article
Rights
© 2024 The Author(s). This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description
Funding: The authors acknowledge financial support from Syngenta, EPSRC (EP/X013081/1) and The Royal Society (University Research Fellowship URF\R1\180017, URF\R\231016, and associated Enhancement Award RGF\EA\181022).
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URI
https://hdl.handle.net/10023/31393

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