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dc.contributor.authorHall, J.
dc.contributor.authorWhalley, H. C.
dc.contributor.authorMcKirdy, J. W.
dc.contributor.authorSprengelmeyer, R.
dc.contributor.authorSantos, I. M.
dc.contributor.authorDonaldson, D. I.
dc.contributor.authorMcGonigle, D. J.
dc.contributor.authorYoung, A. W.
dc.contributor.authorMcIntosh, A. M.
dc.contributor.authorJohnstone, E. C.
dc.contributor.authorLawrie, S. M.
dc.identifier.citationHall , J , Whalley , H C , McKirdy , J W , Sprengelmeyer , R , Santos , I M , Donaldson , D I , McGonigle , D J , Young , A W , McIntosh , A M , Johnstone , E C & Lawrie , S M 2010 , ' A common neural system mediating two different forms of social judgement ' , Psychological Medicine , vol. 40 , no. 7 , pp. 1183-1192 .
dc.identifier.otherPURE: 2061121
dc.identifier.otherPURE UUID: 051d1401-988f-44d9-939f-6a861d774c65
dc.identifier.otherWOS: 000279418000012
dc.identifier.otherScopus: 77956630002
dc.identifier.otherORCID: /0000-0002-3083-5995/work/64697280
dc.description.abstractBackground. A wide range of neuropsychiatric conditions, including schizophrenia and autistic spectrum disorder (ASD), are associated with impairments in social function. Previous studies have shown that individuals with schizophrenia and ASD have deficits in making a wide range of social judgements from faces, including decisions related to threat (such as judgements of approachability) and decisions not related to physical threat (such as judgements of intelligence). We have investigated healthy control participants to see whether there is a common neural system activated during such social decisions, on the basis that deficits in this system may contribute to the impairments seen in these disorders. Method. We investigated the neural basis of social decision making during judgements of approachability and intelligence from faces in 24 healthy participants using functional magnetic resonance imaging (fMRI). We used conjunction analysis to identify common brain regions activated during both tasks. Results. Activation of the amygdala, medial prefrontal cortex, inferior prefrontal cortex and cerebellum was seen during performance of both social tasks, compared to simple gender judgements from the same stimuli. Task-specific activations were present in the dorsolateral prefrontal cortex in the intelligence task and in the inferior and middle temporal cortex in the approachability task. Conclusions. The present study identified a common network of brain regions activated during the performance of two different forms of social judgement from faces. Dysfunction of this network is likely to contribute to the broad-ranging deficits in social function seen in psychiatric disorders such as schizophrenia and ASD.
dc.relation.ispartofPsychological Medicineen
dc.rights(c) Cambridge University Press 2009en
dc.subjectPrefrontal cortexen
dc.subjectCognitive-affective syndromeen
dc.subjectFacial expressionsen
dc.subjectHuman amygdalaen
dc.subjectImpaired recognitionen
dc.subjectBehavioral evidenceen
dc.subjectBrain responsesen
dc.subjectNonverbal tasken
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.titleA common neural system mediating two different forms of social judgementen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.description.statusPeer revieweden

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