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A common neural system mediating two different forms of social judgement

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Hall2010PsychMed40CommonNeural.pdf (253.4Kb)
Date
07/2010
Author
Hall, J.
Whalley, H. C.
McKirdy, J. W.
Sprengelmeyer, R.
Santos, I. M.
Donaldson, D. I.
McGonigle, D. J.
Young, A. W.
McIntosh, A. M.
Johnstone, E. C.
Lawrie, S. M.
Keywords
Amygdala
Faces
fMRI
Prefrontal cortex
Social
Cognitive-affective syndrome
Facial expressions
Human amygdala
Impaired recognition
Behavioral evidence
Brain responses
Nonverbal task
Schizophrenia
Autism
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
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Abstract
Background. A wide range of neuropsychiatric conditions, including schizophrenia and autistic spectrum disorder (ASD), are associated with impairments in social function. Previous studies have shown that individuals with schizophrenia and ASD have deficits in making a wide range of social judgements from faces, including decisions related to threat (such as judgements of approachability) and decisions not related to physical threat (such as judgements of intelligence). We have investigated healthy control participants to see whether there is a common neural system activated during such social decisions, on the basis that deficits in this system may contribute to the impairments seen in these disorders. Method. We investigated the neural basis of social decision making during judgements of approachability and intelligence from faces in 24 healthy participants using functional magnetic resonance imaging (fMRI). We used conjunction analysis to identify common brain regions activated during both tasks. Results. Activation of the amygdala, medial prefrontal cortex, inferior prefrontal cortex and cerebellum was seen during performance of both social tasks, compared to simple gender judgements from the same stimuli. Task-specific activations were present in the dorsolateral prefrontal cortex in the intelligence task and in the inferior and middle temporal cortex in the approachability task. Conclusions. The present study identified a common network of brain regions activated during the performance of two different forms of social judgement from faces. Dysfunction of this network is likely to contribute to the broad-ranging deficits in social function seen in psychiatric disorders such as schizophrenia and ASD.
Citation
Hall , J , Whalley , H C , McKirdy , J W , Sprengelmeyer , R , Santos , I M , Donaldson , D I , McGonigle , D J , Young , A W , McIntosh , A M , Johnstone , E C & Lawrie , S M 2010 , ' A common neural system mediating two different forms of social judgement ' , Psychological Medicine , vol. 40 , no. 7 , pp. 1183-1192 . https://doi.org/10.1017/S0033291709991395
Publication
Psychological Medicine
Status
Peer reviewed
DOI
https://doi.org/10.1017/S0033291709991395
ISSN
0033-2917
Type
Journal article
Rights
(c) Cambridge University Press 2009
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  • University of St Andrews Research
URL
http://www.scopus.com/inward/record.url?scp=77956630002&partnerID=8YFLogxK
URI
http://hdl.handle.net/10023/2998

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