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Mechanophotocatalysis : a generalizable approach to solvent-minimized photocatalytic reactions for organic synthesis
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dc.contributor.author | Millward, Francis D. | |
dc.contributor.author | Zysman-Colman, Eli | |
dc.date.accessioned | 2024-02-20T11:30:03Z | |
dc.date.available | 2024-02-20T11:30:03Z | |
dc.date.issued | 2024-02-19 | |
dc.identifier | 298465637 | |
dc.identifier | 666856e7-5e9d-4b2c-8363-d6ac43b077bd | |
dc.identifier | 85185250192 | |
dc.identifier.citation | Millward , F D & Zysman-Colman , E 2024 , ' Mechanophotocatalysis : a generalizable approach to solvent-minimized photocatalytic reactions for organic synthesis ' , Angewandte Chemie International Edition , vol. Early View , e202316169 . https://doi.org/10.1002/anie.202316169 | en |
dc.identifier.issn | 1433-7851 | |
dc.identifier.other | ORCID: /0000-0001-7183-6022/work/153977836 | |
dc.identifier.uri | https://hdl.handle.net/10023/29297 | |
dc.description | The authors thank the Leverhulme Trust (RPG-2023-110), the Engineering and Physical Sciences Research Council for funding (EP/W007517, EP/W015137/1) and the European Commission (PhotoReAct ITN: 956324). F. M. thanks the EaSI-CAT CDT at the University of St Andrews for support in the form of a studentship. | en |
dc.description.abstract | This proof-of-concept study cements the viability and generality of mechanophotocatalysis, merging mechanochemistry and photocatalysis to enable solvent-minimized photocatalytic reactions. We demonstrate the transmutation of four archetypal solution-state photocatalysis reactions to a solvent-minimized environment driven by the combined actions of milling, light, and photocatalysts. The chlorosulfonylation of alkenes and the pinacol coupling of aldehydes and ketones were conducted under solvent-free conditions with competitive or superior efficiencies to their solution-state analogues. Furthermore, decarboxylative alkylations are shown to function efficiently under solvent-minimized conditions, while the photoinduced energy transfer promoted [2+2] cycloaddition of chalcone experiences a significant initial rate enhancement over its solution-state variant. This work serves as a platform for future discoveries in an underexplored field: validating that solvent-minimized photocatalysis is not only generalizable and competitive with solution-state photocatalysis, but can also offer valuable advantages. | |
dc.format.extent | 10 | |
dc.format.extent | 2139362 | |
dc.language.iso | eng | |
dc.relation.ispartof | Angewandte Chemie International Edition | en |
dc.subject | Mechanochemistry | en |
dc.subject | Photocatalysis | en |
dc.subject | Synthetic methods | en |
dc.subject | Mechanophotocatalysis | en |
dc.subject | Radicals | en |
dc.subject | QD Chemistry | en |
dc.subject | DAS | en |
dc.subject.lcc | QD | en |
dc.title | Mechanophotocatalysis : a generalizable approach to solvent-minimized photocatalytic reactions for organic synthesis | en |
dc.type | Journal article | en |
dc.contributor.sponsor | UK Research and Innovation | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.sponsor | European Commission | en |
dc.contributor.sponsor | The Leverhulme Trust | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Centre for Energy Ethics | en |
dc.contributor.institution | University of St Andrews. Organic Semiconductor Centre | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.identifier.doi | 10.1002/anie.202316169 | |
dc.description.status | Peer reviewed | en |
dc.identifier.grantnumber | EP/W007517/1 | en |
dc.identifier.grantnumber | EP/W015137/1 | en |
dc.identifier.grantnumber | 956324 | en |
dc.identifier.grantnumber | ORPG-10966 | en |
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