Mechanophotocatalysis : a generalizable approach to solvent-minimized photocatalytic reactions for organic synthesis
Date
19/02/2024Grant ID
EP/W007517/1
EP/W015137/1
956324
ORPG-10966
Keywords
Metadata
Show full item recordAbstract
This proof-of-concept study cements the viability and generality of mechanophotocatalysis, merging mechanochemistry and photocatalysis to enable solvent-minimized photocatalytic reactions. We demonstrate the transmutation of four archetypal solution-state photocatalysis reactions to a solvent-minimized environment driven by the combined actions of milling, light, and photocatalysts. The chlorosulfonylation of alkenes and the pinacol coupling of aldehydes and ketones were conducted under solvent-free conditions with competitive or superior efficiencies to their solution-state analogues. Furthermore, decarboxylative alkylations are shown to function efficiently under solvent-minimized conditions, while the photoinduced energy transfer promoted [2+2] cycloaddition of chalcone experiences a significant initial rate enhancement over its solution-state variant. This work serves as a platform for future discoveries in an underexplored field: validating that solvent-minimized photocatalysis is not only generalizable and competitive with solution-state photocatalysis, but can also offer valuable advantages.
Citation
Millward , F D & Zysman-Colman , E 2024 , ' Mechanophotocatalysis : a generalizable approach to solvent-minimized photocatalytic reactions for organic synthesis ' , Angewandte Chemie International Edition , vol. Early View , e202316169 . https://doi.org/10.1002/anie.202316169
Publication
Angewandte Chemie International Edition
Status
Peer reviewed
ISSN
1433-7851Type
Journal article
Description
The authors thank the Leverhulme Trust (RPG-2023-110), the Engineering and Physical Sciences Research Council for funding (EP/W007517, EP/W015137/1) and the European Commission (PhotoReAct ITN: 956324). F. M. thanks the EaSI-CAT CDT at the University of St Andrews for support in the form of a studentship.Collections
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