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Unveiling the impact of a CF2 motif in the isothiourea catalyst skeleton : evaluating C(3)-F2-HBTM and its catalytic activity

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dc.contributor.authorWestwood, Matthew
dc.contributor.authorKasten, Kevin
dc.contributor.authorStockhammer, Lotte
dc.contributor.authordel Río-Rodríguez, Roberto
dc.contributor.authorFernández-Salas, Jose A.
dc.contributor.authorEitzinger, Andreas
dc.contributor.authorSlawin, Alexandra M. Z.
dc.contributor.authorWaser, Mario
dc.contributor.authorAlémán, Jose
dc.contributor.authorOfial, Armin R.
dc.contributor.authorSmith, Andrew D.
dc.date.accessioned2024-02-08T09:30:02Z
dc.date.available2024-02-08T09:30:02Z
dc.date.issued2023-12-31
dc.identifier297363097
dc.identifier7bcf11c3-cf02-465e-ad7d-09ac043db517
dc.identifier85180339646
dc.identifier.citationWestwood , M , Kasten , K , Stockhammer , L , del Río-Rodríguez , R , Fernández-Salas , J A , Eitzinger , A , Slawin , A M Z , Waser , M , Alémán , J , Ofial , A R & Smith , A D 2023 , ' Unveiling the impact of a CF 2 motif in the isothiourea catalyst skeleton : evaluating C(3)-F 2 -HBTM and its catalytic activity ' , ARKIVOC , vol. 2024 , no. 4 , 202312093 . https://doi.org/10.24820/ark.5550190.p012.093en
dc.identifier.issn1551-7004
dc.identifier.otherORCID: /0000-0002-9527-6418/work/152899127
dc.identifier.otherORCID: /0000-0002-2104-7313/work/152899479
dc.identifier.urihttps://hdl.handle.net/10023/29190
dc.descriptionThe St Andrews Team (A. D. S., K. K., M. T. W.) thanks the EaSI-CAT centre for Doctoral Training (MTW) and the EPSRC (EP/T023643/1; KK). The Linz team (L. S., A. E., M. W.) gratefully acknowledges generous financial support by the Austrian Science Funds (FWF) through project No. P31784, the Erasmus+ program and the JKU Linz/Upper Austria scheme. The Madrid team (J. A. F.-S., J. A., R. d. R-R.) gratefully acknowledges the Spanish Government (RTI2018-095038-B-100), “Communidad de Madrid” for European Structural Funds (S2018/NMT-4367) and proyectos sinergicos I + D (Y2020/NMT-6469) for funding. J. A. F.-S. thanks the Spanish government for a Ramón y Cajal contract.en
dc.description.abstractThe incorporation of the CF2 motif within organic structures is known to affect the susceptibility of functional groups to oxidation, as well as altering conformation and reactivity. In this manuscript, the incorporation of the CF2 functional group within an isothiourea catalyst skeleton to give C(3)-F2-HBTM is reported. Effective gram-scale routes to both racemic and enantiopure heterocyclic Lewis bases are developed, with preliminary catalytic and kinetic activity evaluated.
dc.format.extent23
dc.format.extent1664492
dc.language.isoeng
dc.relation.ispartofARKIVOCen
dc.subjectIsothioureaen
dc.subjectFluorinationen
dc.subjectAsymmetric synthesisen
dc.subjectPhotocatalysisen
dc.subjectQD Chemistryen
dc.subjectDASen
dc.subject.lccQDen
dc.titleUnveiling the impact of a CF2 motif in the isothiourea catalyst skeleton : evaluating C(3)-F2-HBTM and its catalytic activityen
dc.typeJournal articleen
dc.contributor.sponsorEPSRCen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.identifier.doi10.24820/ark.5550190.p012.093
dc.description.statusPeer revieweden
dc.identifier.grantnumberEP/T023643/1en


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