Unveiling the impact of a CF2 motif in the isothiourea catalyst skeleton : evaluating C(3)-F2-HBTM and its catalytic activity
Abstract
The incorporation of the CF2 motif within organic structures is known to affect the susceptibility of functional groups to oxidation, as well as altering conformation and reactivity. In this manuscript, the incorporation of the CF2 functional group within an isothiourea catalyst skeleton to give C(3)-F2-HBTM is reported. Effective gram-scale routes to both racemic and enantiopure heterocyclic Lewis bases are developed, with preliminary catalytic and kinetic activity evaluated.
Citation
Westwood , M , Kasten , K , Stockhammer , L , del Río-Rodríguez , R , Fernández-Salas , J A , Eitzinger , A , Slawin , A M Z , Waser , M , Alémán , J , Ofial , A R & Smith , A D 2023 , ' Unveiling the impact of a CF 2 motif in the isothiourea catalyst skeleton : evaluating C(3)-F 2 -HBTM and its catalytic activity ' , ARKIVOC , vol. 2024 , no. 4 , 202312093 . https://doi.org/10.24820/ark.5550190.p012.093
Publication
ARKIVOC
Status
Peer reviewed
ISSN
1551-7004Type
Journal article
Description
The St Andrews Team (A. D. S., K. K., M. T. W.) thanks the EaSI-CAT centre for Doctoral Training (MTW) and the EPSRC (EP/T023643/1; KK). The Linz team (L. S., A. E., M. W.) gratefully acknowledges generous financial support by the Austrian Science Funds (FWF) through project No. P31784, the Erasmus+ program and the JKU Linz/Upper Austria scheme. The Madrid team (J. A. F.-S., J. A., R. d. R-R.) gratefully acknowledges the Spanish Government (RTI2018-095038-B-100), “Communidad de Madrid” for European Structural Funds (S2018/NMT-4367) and proyectos sinergicos I + D (Y2020/NMT-6469) for funding. J. A. F.-S. thanks the Spanish government for a Ramón y Cajal contract.Collections
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