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3′-O-β-Glucosyl-4′,5′-didehydro-5′-deoxyadenosine is a natural product of the nucleocidin producers Streptomyces virens and Streptomyces calvus
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dc.contributor.author | Clarke, David | |
dc.contributor.author | Feng, Xuan | |
dc.contributor.author | Deng, Hai | |
dc.contributor.author | Zhang, Qingzhi | |
dc.contributor.author | O'Hagan, David | |
dc.date.accessioned | 2023-09-26T16:30:20Z | |
dc.date.available | 2023-09-26T16:30:20Z | |
dc.date.issued | 2023-10-27 | |
dc.identifier | 293900941 | |
dc.identifier | c7becf53-b775-4df7-a028-a8e8bd194e5e | |
dc.identifier | 85174955853 | |
dc.identifier.citation | Clarke , D , Feng , X , Deng , H , Zhang , Q & O'Hagan , D 2023 , ' 3′- O -β-Glucosyl-4′,5′-didehydro-5′-deoxyadenosine is a natural product of the nucleocidin producers Streptomyces virens and Streptomyces calvus ' , Journal of Natural Products , vol. 86 , no. 10 , pp. 2326-2332 . https://doi.org/10.1021/acs.jnatprod.3c00521 | en |
dc.identifier.issn | 0163-3864 | |
dc.identifier.other | ORCID: /0000-0002-0510-5552/work/143335881 | |
dc.identifier.uri | https://hdl.handle.net/10023/28455 | |
dc.description | Funding: Leverhulme Trust - RPG-2021-028. | en |
dc.description.abstract | 3′-O-β-Glucosyl-4′,5′-didehydro-5′-deoxyadenosine 13 is identified as a natural product of Streptomyces calvus and Streptomyces virens. It is also generated in vitro by direct β-glucosylation of 4′,5′-didehydro-5′-deoxyadenosine 12 with the enzyme NucGT. The intact incorporation of oxygen-18 and deuterium isotopes from (±)[1-18O,1-2H2]-glycerol 14 into C-5′ of nucleocidin 1 and its related metabolites precludes 3′-O-β-glucosyl-4′,5′-didehydro-5′-deoxyadenosine 13 as a biosynthetic precursor to nucleocidin 1. | |
dc.format.extent | 7 | |
dc.format.extent | 2521908 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Natural Products | en |
dc.subject | QD Chemistry | en |
dc.subject | NDAS | en |
dc.subject | MCC | en |
dc.subject.lcc | QD | en |
dc.title | 3′-O-β-Glucosyl-4′,5′-didehydro-5′-deoxyadenosine is a natural product of the nucleocidin producers Streptomyces virens and Streptomyces calvus | en |
dc.type | Journal article | en |
dc.contributor.sponsor | The Leverhulme Trust | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Institute of Behavioural and Neural Sciences | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | https://doi.org/10.1021/acs.jnatprod.3c00521 | |
dc.description.status | Peer reviewed | en |
dc.identifier.grantnumber | RPG-2021-028 | en |
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