3′-O-β-Glucosyl-4′,5′-didehydro-5′-deoxyadenosine is a natural product of the nucleocidin producers Streptomyces virens and Streptomyces calvus
Abstract
3′-O-β-Glucosyl-4′,5′-didehydro-5′-deoxyadenosine 13 is identified as a natural product of Streptomyces calvus and Streptomyces virens. It is also generated in vitro by direct β-glucosylation of 4′,5′-didehydro-5′-deoxyadenosine 12 with the enzyme NucGT. The intact incorporation of oxygen-18 and deuterium isotopes from (±)[1-18O,1-2H2]-glycerol 14 into C-5′ of nucleocidin 1 and its related metabolites precludes 3′-O-β-glucosyl-4′,5′-didehydro-5′-deoxyadenosine 13 as a biosynthetic precursor to nucleocidin 1.
Citation
Clarke , D , Feng , X , Deng , H , Zhang , Q & O'Hagan , D 2023 , ' 3′- O -β-Glucosyl-4′,5′-didehydro-5′-deoxyadenosine is a natural product of the nucleocidin producers Streptomyces virens and Streptomyces calvus ' , Journal of Natural Products , vol. 86 , no. 10 , pp. 2326-2332 . https://doi.org/10.1021/acs.jnatprod.3c00521
Publication
Journal of Natural Products
Status
Peer reviewed
ISSN
0163-3864Type
Journal article
Description
Funding: Leverhulme Trust - RPG-2021-028.Collections
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