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Dyslexia-related loci are significantly associated with language and literacy in Chinese–English bilingual Hong Kong Chinese twins

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dc.contributor.authorChung, Cheuk Yan
dc.contributor.authorPan, Dora Jue
dc.contributor.authorParacchini, Silvia
dc.contributor.authorJiang, Wenxuan
dc.contributor.authorSo, Hon-Cheong
dc.contributor.authorMcBride, Catherine
dc.contributor.authorMaurer, Urs
dc.contributor.authorZheng, Mo
dc.contributor.authorChoy, Kwong Wai
dc.date.accessioned2023-09-07T11:30:07Z
dc.date.available2023-09-07T11:30:07Z
dc.date.issued2023-09-05
dc.identifier.citationChung , C Y , Pan , D J , Paracchini , S , Jiang , W , So , H-C , McBride , C , Maurer , U , Zheng , M & Choy , K W 2023 , ' Dyslexia-related loci are significantly associated with language and literacy in Chinese–English bilingual Hong Kong Chinese twins ' , Human Genetics . https://doi.org/10.21203/rs.3.rs-2887801/v1 , https://doi.org/10.1007/s00439-023-02594-6en
dc.identifier.issn0340-6717
dc.identifier.otherPURE: 293710357
dc.identifier.otherPURE UUID: 309ca016-8c7f-46f6-8cb5-00f0dbe5469f
dc.identifier.otherORCID: /0000-0001-9934-8602/work/142064222
dc.identifier.otherScopus: 85169881282
dc.identifier.urihttp://hdl.handle.net/10023/28327
dc.descriptionThis study was partially funded by the Research Grants Council of the Hong Kong Special Administration Region (C4054-17WF) and the Theme-based Research Scheme from the Hong Kong Special Administrative Region Research Grants Council (T44-410/21-N).en
dc.description.abstractA recent genome-wide association study on dyslexia in 51,800 affected European adults and 1,087,070 controls detected 42 genome-wide significant single nucleotide variants (SNPs). The association between rs2624839 in SEMA3F and reading fluency was replicated in a Chinese cohort. This study explores the genetic overlap between Chinese and English word reading, vocabulary knowledge and spelling, and aims at replicating the association in a unique cohort of bilingual (Chinese–English) Hong Kong Chinese twins. Our result showed an almost complete genetic overlap in vocabulary knowledge (r2 = 0.995), and some genetic overlaps in word reading and spelling (r2 = 0.846, 0.687) across the languages. To investigate the region near rs2624839, we tested proxy SNPs (rs1005678, rs12632110 and rs12494414) at the population level (n = 305–308) and the within-twin level (n = 342–344 [171–172 twin pairs]). All the three SNPs showed significant associations with quantitative Chinese and English vocabulary knowledge (p 
dc.language.isoeng
dc.relation.ispartofHuman Geneticsen
dc.rightsCopyright © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. This work has been made available online in accordance with the Rights Retention Strategy This accepted manuscript is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The final published version of this work is available at https://doi.org/10.1007/s00439-023-02594-6.en
dc.subjectQH301 Biologyen
dc.subjectQH426 Geneticsen
dc.subjectATC-NDASen
dc.subjectACen
dc.subject.lccQH301en
dc.subject.lccQH426en
dc.titleDyslexia-related loci are significantly associated with language and literacy in Chinese–English bilingual Hong Kong Chinese twinsen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Centre for Biophotonicsen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.contributor.institutionUniversity of St Andrews. St Andrews Bioinformatics Uniten
dc.contributor.institutionUniversity of St Andrews. Cellular Medicine Divisionen
dc.identifier.doihttps://doi.org/10.21203/rs.3.rs-2887801/v1
dc.description.statusPeer revieweden


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