Dyslexia-related loci are significantly associated with language and literacy in Chinese–English bilingual Hong Kong Chinese twins
Abstract
A recent genome-wide association study on dyslexia in 51,800 affected European adults and 1,087,070 controls detected 42 genome-wide significant single nucleotide variants (SNPs). The association between rs2624839 in SEMA3F and reading fluency was replicated in a Chinese cohort. This study explores the genetic overlap between Chinese and English word reading, vocabulary knowledge and spelling, and aims at replicating the association in a unique cohort of bilingual (Chinese–English) Hong Kong Chinese twins. Our result showed an almost complete genetic overlap in vocabulary knowledge (r2 = 0.995), and some genetic overlaps in word reading and spelling (r2 = 0.846, 0.687) across the languages. To investigate the region near rs2624839, we tested proxy SNPs (rs1005678, rs12632110 and rs12494414) at the population level (n = 305–308) and the within-twin level (n = 342–344 [171–172 twin pairs]). All the three SNPs showed significant associations with quantitative Chinese and English vocabulary knowledge (p
Citation
Chung , C Y , Pan , D J , Paracchini , S , Jiang , W , So , H-C , McBride , C , Maurer , U , Zheng , M & Choy , K W 2023 , ' Dyslexia-related loci are significantly associated with language and literacy in Chinese–English bilingual Hong Kong Chinese twins ' , Human Genetics . https://doi.org/10.21203/rs.3.rs-2887801/v1 , https://doi.org/10.1007/s00439-023-02594-6
Publication
Human Genetics
Status
Peer reviewed
ISSN
0340-6717Type
Journal article
Rights
Copyright © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. This work has been made available online in accordance with the Rights Retention Strategy This accepted manuscript is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The final published version of this work is available at https://doi.org/10.1007/s00439-023-02594-6.
Description
This study was partially funded by the Research Grants Council of the Hong Kong Special Administration Region (C4054-17WF) and the Theme-based Research Scheme from the Hong Kong Special Administrative Region Research Grants Council (T44-410/21-N).Collections
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