The metabolic features of tumor-associated macrophages : opportunities for immunotherapy?
Abstract
Besides transformed cells, the tumors are composed of various cell types that contribute to undesirable tumor progression. Tumor-associated macrophages (TAMs) are the most abundant innate immune cells in the tumor microenvironment (TME). Within the TME, TAMs exhibit high plasticity and undergo specific functional metabolic alterations according to the availability of tumor tissue oxygen and nutrients, thus further contributing to tumorigenesis and cancer progression. Here, we review the main functional TAM metabolic patterns influenced by TME, including glycolysis, amino acid, and fatty acid metabolism. Moreover, this review discusses antitumor immunotherapies that affect TAM functionality by inducing cell repolarizing and metabolic profiles towards an antitumoral phenotype. Also, new macrophage-based cell therapeutic technologies recently developed using chimeric antigen receptor bioengineering are exposed, which may overcome all solid tumor physical barriers impeding the current adoptive cell therapies and contribute to developing novel cancer immunotherapies.
Citation
Mojsilovic , S S , Mojsilovic , S , Villar , V H & Santibanez , J F 2021 , ' The metabolic features of tumor-associated macrophages : opportunities for immunotherapy? ' , Analytical Cellular Pathology , vol. 2021 , 5523055 . https://doi.org/10.1155/2021/5523055
Publication
Analytical Cellular Pathology
Status
Peer reviewed
ISSN
2210-7177Type
Journal item
Description
Funding: This work was supported by the Ministry of Education, Science, and Technological Development of the Republic of Serbia.Collections
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