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Magnesium deficiency and cardiometabolic disease

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Nutrients_15_2355.pdf (986.0Kb)
Date
17/05/2023
Author
Fritzen, Remi
Davies, Amy
Veenhuizen, Miriam
Campbell, Matthew
Pitt, Samantha J.
Ajjan, Ramzi A.
Stewart, Alan J.
Funder
BBSRC
Grant ID
BB/V014684/1
Keywords
Cardiovascular disease
Magnesium
Metal ion dyshomeostasis
Nutrient deficiency
Supplementation
QH301 Biology
RA0421 Public health. Hygiene. Preventive Medicine
T-DAS
SDG 3 - Good Health and Well-being
MCC
Metadata
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Abstract
Magnesium (Mg2+) has many physiological functions within the body. These include important roles in maintaining cardiovascular functioning, where it contributes to the regulation of cardiac excitation–contraction coupling, endothelial functioning and haemostasis. The haemostatic roles of Mg2+ impact upon both the protein and cellular arms of coagulation. In this review, we examine how Mg2+ homeostasis is maintained within the body and highlight the various molecular roles attributed to Mg2+ in the cardiovascular system. In addition, we describe how nutritional and/or disease-associated magnesium deficiency, seen in some metabolic conditions, has the potential to influence cardiac and vascular outcomes. Finally, we also examine the potential for magnesium supplements to be employed in the prevention and treatment of cardiovascular disorders and in the management of cardiometabolic health.
Citation
Fritzen , R , Davies , A , Veenhuizen , M , Campbell , M , Pitt , S J , Ajjan , R A & Stewart , A J 2023 , ' Magnesium deficiency and cardiometabolic disease ' , Nutrients , vol. 15 , no. 10 , 2355 . https://doi.org/10.3390/nu15102355
Publication
Nutrients
Status
Peer reviewed
DOI
https://doi.org/10.3390/nu15102355
ISSN
2072-6643
Type
Journal article
Rights
Copyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Description
Funding: R.F. is supported by the Biological and Biotechnological Sciences Research Council.
Collections
  • University of St Andrews Research
URL
https://www.mdpi.com/2072-6643/15/10/2355
URI
http://hdl.handle.net/10023/27641

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