Magnesium deficiency and cardiometabolic disease
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Magnesium (Mg2+) has many physiological functions within the body. These include important roles in maintaining cardiovascular functioning, where it contributes to the regulation of cardiac excitation–contraction coupling, endothelial functioning and haemostasis. The haemostatic roles of Mg2+ impact upon both the protein and cellular arms of coagulation. In this review, we examine how Mg2+ homeostasis is maintained within the body and highlight the various molecular roles attributed to Mg2+ in the cardiovascular system. In addition, we describe how nutritional and/or disease-associated magnesium deficiency, seen in some metabolic conditions, has the potential to influence cardiac and vascular outcomes. Finally, we also examine the potential for magnesium supplements to be employed in the prevention and treatment of cardiovascular disorders and in the management of cardiometabolic health.
Fritzen , R , Davies , A , Veenhuizen , M , Campbell , M , Pitt , S J , Ajjan , R A & Stewart , A J 2023 , ' Magnesium deficiency and cardiometabolic disease ' , Nutrients , vol. 15 , no. 10 , 2355 . https://doi.org/10.3390/nu15102355
Copyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
DescriptionFunding: R.F. is supported by the Biological and Biotechnological Sciences Research Council.
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