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Chiropterans are a hotspot for horizontal transfer of DNA transposons in mammalia

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dc.contributor.authorPaulat, Nicole S
dc.contributor.authorStorer, Jessica M
dc.contributor.authorMoreno-Santillán, Diana D
dc.contributor.authorOsmanski, Austin B
dc.contributor.authorSullivan, Kevin A M
dc.contributor.authorGrimshaw, Jenna R
dc.contributor.authorKorstian, Jennifer
dc.contributor.authorHalsey, Michaela
dc.contributor.authorGarcia, Carlos J
dc.contributor.authorCrookshanks, Claudia
dc.contributor.authorRoberts, Jaquelyn
dc.contributor.authorSmit, Arian F A
dc.contributor.authorHubley, Robert
dc.contributor.authorRosen, Jeb
dc.contributor.authorTeeling, Emma C
dc.contributor.authorVernes, Sonja C
dc.contributor.authorMyers, Eugene
dc.contributor.authorPippel, Martin
dc.contributor.authorBrown, Thomas
dc.contributor.authorHiller, Michael
dc.contributor.authorConsortium, Zoonomia
dc.contributor.authorRojas, Danny
dc.contributor.authorDávalos, Liliana M
dc.contributor.authorLindblad-Toh, Kerstin
dc.contributor.authorKarlsson, Elinor K
dc.contributor.authorRay, David A
dc.date.accessioned2023-05-09T15:30:04Z
dc.date.available2023-05-09T15:30:04Z
dc.date.issued2023-05-01
dc.identifier285682472
dc.identifier0dd12c71-4adf-426e-a097-af3f429aad64
dc.identifier85159552469
dc.identifier.citationPaulat , N S , Storer , J M , Moreno-Santillán , D D , Osmanski , A B , Sullivan , K A M , Grimshaw , J R , Korstian , J , Halsey , M , Garcia , C J , Crookshanks , C , Roberts , J , Smit , A F A , Hubley , R , Rosen , J , Teeling , E C , Vernes , S C , Myers , E , Pippel , M , Brown , T , Hiller , M , Consortium , Z , Rojas , D , Dávalos , L M , Lindblad-Toh , K , Karlsson , E K & Ray , D A 2023 , ' Chiropterans are a hotspot for horizontal transfer of DNA transposons in mammalia ' , Molecular Biology and Evolution , vol. 40 , no. 5 , msad092 . https://doi.org/10.1093/molbev/msad092en
dc.identifier.issn1537-1719
dc.identifier.otherBibtex: 10.1093/molbev/msad092
dc.identifier.otherORCID: /0000-0003-0305-4584/work/135018862
dc.identifier.urihttps://hdl.handle.net/10023/27546
dc.descriptionFunding: This project was supported by the National Science Foundation (grant numbers DEB 1838283 and IOS 2032006 to D.M.-S. and Dav.R. and DEB 1838273 and DGE 1633299 to L.D.), National Institutes of Health (grant numbers R01HG002939 and U24HG010136 to J.S., R.H., A.F.A.S., and Je.R.), NHGRI (grant number R01HG008742 to Z.C.), Irish Research Council (grant number IRCLA/ 2017/58 to E.T.), Science Foundation Ireland (grant number 19/FFP/6790 to E.T.), Max Planck Research Group awarded by the Max Planck Gesellschaft to S.V., Human Frontiers Science Program (grant number RGP0058/2016 to S.V.), UK Research and Innovation (grant number MR/T021985/1 to S.V.), and the Swedish Research Council Distinguished Professor Award to K.L.-T.en
dc.description.abstractHorizontal transfer of transposable elements (TEs) is an important mechanism contributing to genetic diversity and innovation. Bats (order Chiroptera) have repeatedly been shown to experience horizontal transfer of TEs at what appears to be a high rate compared with other mammals. We investigated the occurrence of horizontally transferred (HT) DNA transposons involving bats. We found over 200 putative HT elements within bats; 16 transposons were shared across distantly related mammalian clades, and 2 other elements were shared with a fish and two lizard species. Our results indicate that bats are a hotspot for horizontal transfer of DNA transposons. These events broadly coincide with the diversification of several bat clades, supporting the hypothesis that DNA transposon invasions have contributed to genetic diversification of bats.
dc.format.extent14
dc.format.extent1930941
dc.language.isoeng
dc.relation.ispartofMolecular Biology and Evolutionen
dc.subjectFusogenic envelope proteinen
dc.subjectPlatypusen
dc.subjectEndogenous retrovirusen
dc.subjectEchidnaen
dc.subjectMonotremesen
dc.subjectQH426 Geneticsen
dc.subjectDASen
dc.subjectACen
dc.subjectMCCen
dc.subject.lccQH426en
dc.titleChiropterans are a hotspot for horizontal transfer of DNA transposons in mammaliaen
dc.typeJournal articleen
dc.contributor.sponsorUK Research and Innovationen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.contributor.institutionUniversity of St Andrews. St Andrews Bioinformatics Uniten
dc.identifier.doi10.1093/molbev/msad092
dc.description.statusPeer revieweden
dc.identifier.grantnumberMR/T021985/1en


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