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222-nm UVC light as a skin-safe solution to antimicrobial resistance in acute hospital settings with a particular focus on methicillin-resistant Staphylococcus aureus and surgical site infections : a review

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Date
03/03/2023
Author
Panzures, Alexis
Keywords
UV light
Surgical site infection
MRSA
Skin
Disinfection
RA0421 Public health. Hygiene. Preventive Medicine
QR Microbiology
SDG 3 - Good Health and Well-being
MCC
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Abstract
The increasing burden of antimicrobial resistance necessitates a novel approach to disinfect multidrug resistant pathogens. Conventional 254-nm ultraviolet-C (UVC) light shows high germicidal efficacy against bacteria. However, it induces pyrimidine dimerization in exposed human skin with carcinogenic potential. Recent developments suggest 222-nm UVC light can be used to disinfect bacteria and cause less harm to human DNA. This new technology can be used to disinfect healthcare-associated infections and more specifically surgical site infections (SSIs). This includes but is not limited to methicillin-resistant Staphylococcus aureus (MRSA), P. aeruginosa, C. difficile, E. coli, and other aerobic bacteria. This thorough review of scarce literature assesses the germicidal efficacy and skin safety of 222-nm UVC light with a particular focus on its clinical applications to MRSA and SSIs. The study reviews a variety of experimental models, including in vivo and in vitro cell cultures, live human skin, human skin models, mice skin, and rabbit skin. The potential for long-term eradication of bacteria and efficacy against specific pathogens is appraised. This paper focuses on the methods and models used in past and present research to determine the efficacy and safety of 222-nm UVC in the acute hospital setting with a focus on MRSA and its applicability to SSIs.
Citation
Panzures , A & Hammond , R (Guest ed.) 2023 , ' 222-nm UVC light as a skin-safe solution to antimicrobial resistance in acute hospital settings with a particular focus on methicillin-resistant Staphylococcus aureus and surgical site infections : a review ' , Journal of Applied Microbiology , vol. 134 , no. 3 , lxad046 . https://doi.org/10.1093/jambio/lxad046
Publication
Journal of Applied Microbiology
Status
Peer reviewed
DOI
https://doi.org/10.1093/jambio/lxad046
ISSN
1364-5072
Type
Journal item
Rights
Copyright The Author(s) 2023. Published by Oxford University Press on behalf of Applied Microbiology International. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/27349

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