Now showing items 1-7 of 7

  • Building a genomic framework for prospective MRSA surveillance in the United Kingdom and the Republic of Ireland 

    Reuter, Sandra; Török, Estee M; Holden, Matthew Tg; Reynolds, Rosy; Raven, Kathy E; Blane, Beth; Donker, Tjibbe; Bentley, Stephen D; Aanensen, David M; Grundmann, Hajo; Feil, Edward J; Spratt, Brian G; Parkhill, Julian; Peacock, Sharon J (2016-02) - Journal article
    The correct interpretation of microbial sequencing data applied to surveillance and outbreak investigation depends on accessible genomic databases to provide vital genetic context. Our aim was to construct and describe a ...
  • Methicillin-resistant Staphylococcus aureus emerged long before the introduction of methicillin into clinical practice 

    Harkins, Catriona P.; Pichon, Bruno; Doumith, Michel; Parkhill, Julian; Westh, Henrik; Tomasz, Alexander; de Lencastre, Herminia; Bentley, Stephen D.; Kearns, Angela M.; Holden, Matthew T. G. (2017-07-20) - Journal article
    Background: The spread of drug-resistant bacterial pathogens poses a major threat to global health. It is widely recognised that the widespread use of antibiotics has generated selective pressures that have driven the ...
  • A novel hybrid SCCmec-mecC region in Staphylococcus sciuri 

    Harrison, Ewan M; Paterson, Gavin K; Holden, Matthew T G; Ba, Xiaoliang; Rolo, Joana; Morgan, Fiona J E; Pichon, Bruno; Kearns, Angela; Zadoks, Ruth N; Peacock, Sharon J; Parkhill, Julian; Holmes, Mark A (2014-04) - Journal article
    Methicillin resistance in Staphylococcus spp. results from the expression of an alternative penicillin-binding protein 2a (encoded by mecA) with a low affinity for β-lactam antibiotics. Recently, a novel variant of mecA ...
  • Pan-genomic perspective on the evolution of the Staphylococcus aureus USA300 epidemic 

    Jamrozy, Dorota M.; Harris, Simon R.; Mohamed, Naglaa; Peacock, Sharon J.; Tan, Charles Y.; Parkhill, Julian; Anderson, Annaliesa S.; Holden, Matthew T. G. (2016-05-31) - Journal article
    Staphylococcus aureus USA300 represents the dominant community-associated methicillin-resistant S. aureus lineage in the USA, where it is a major cause of skin and soft tissue infections. Previous comparative genomic studies ...
  • Population genetic structuring of methicillin-resistant Staphylococcus aureus clone EMRSA-15 within UK reflects patient referral patterns 

    Donker, Tjibbe; Reuter, Sandra; Scriberras, James; Reynolds, Rosy; Brown, Nicholas M; Török, M Estée; James, Richard; Network, East Of England Microbiology Research; Aanensen, David M; Bentley, Stephen D; Holden, Matthew T. G.; Parkhill, Julian; Spratt, Brian G; Peacock, Sharon J; Feil, Edward J; Grundmann, Hajo (2017-07-09) - Journal article
    Antibiotic resistance forms a serious threat to the health of hospitalised patients, rendering otherwise treatable bacterial infections potentially life-threatening. A thorough understanding of the mechanisms by which ...
  • Single-molecule sequencing reveals the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus 

    Steinig, Eike J; Andersson, Patiyan; Harris, Simon R; Sarovich, Derek S; Manoharan, Anand; Coupland, Paul; Holden, Matthew Tg; Parkhill, Julian; Bentley, Stephen D; Robinson, D Ashley; Tong, Steven Yc (2015-05-16) - Journal article
    Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-associated infection, but there is growing awareness of the emergence of multidrug-resistant lineages in community settings around the world. ...
  • Structural analysis of the potential therapeutic targets from specific genes in Methicillin-resistant Staphylococcus aureus (MRSA) 

    Yan, Xuan (University of St Andrews, 2011-11-01) - Thesis
    The thesis describes over-expression, purification and crystallization of three proteins from Staphylococcus aureus (S. aureus). S. aureus is an important human pathogen and methicillin-resistant S. aureus (MRSA) is a ...