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dc.contributor.authorDesai, Aamod Vikas
dc.contributor.authorVornholt, Simon M.
dc.contributor.authorMajor, Louise L
dc.contributor.authorEttlinger, Romy
dc.contributor.authorJansen, Christian
dc.contributor.authorRainer, Daniel
dc.contributor.authorde Rome, Richard
dc.contributor.authorSo, Venus
dc.contributor.authorWheatley, Paul S.
dc.contributor.authorEdward, Ailsa K.
dc.contributor.authorElliott, Caroline
dc.contributor.authorPramanik, Atin
dc.contributor.authorKarmakar, Avishek
dc.contributor.authorArmstrong, Robert
dc.contributor.authorJaniak, Christoph
dc.contributor.authorSmith, Terry K
dc.contributor.authorMorris, Russell Edward
dc.date.accessioned2023-02-14T12:30:05Z
dc.date.available2023-02-14T12:30:05Z
dc.date.issued2023-02-22
dc.identifier.citationDesai , A V , Vornholt , S M , Major , L L , Ettlinger , R , Jansen , C , Rainer , D , de Rome , R , So , V , Wheatley , P S , Edward , A K , Elliott , C , Pramanik , A , Karmakar , A , Armstrong , R , Janiak , C , Smith , T K & Morris , R E 2023 , ' Surface-Functionalized Metal-Organic Frameworks for Binding Coronavirus Proteins ' , ACS Applied Materials & Interfaces , vol. 15 , no. 7 , pp. 9058–9065 . https://doi.org/10.1021/acsami.2c21187 , https://doi.org/10.1021/acsami.2c21187en
dc.identifier.issn1944-8244
dc.identifier.otherPURE: 282894842
dc.identifier.otherPURE UUID: e14c7ee9-1313-43f9-99e4-d7efd0f7a022
dc.identifier.otherWOS: 000933969800001
dc.identifier.otherORCID: /0000-0001-7219-3428/work/129146228
dc.identifier.otherORCID: /0000-0001-7809-0315/work/129147971
dc.identifier.otherORCID: /0000-0001-5287-4488/work/129148071
dc.identifier.otherORCID: /0000-0003-1937-0936/work/129148162
dc.identifier.otherScopus: 85148365989
dc.identifier.otherWOS: 000933969800001
dc.identifier.otherPubMed: 36786318
dc.identifier.urihttps://hdl.handle.net/10023/26979
dc.descriptionFunding: This work was supported by University of St Andrews Restarting Research Funding Scheme (SARRF), funded through the SFC grant reference SFC/AN/08/020 (XRR064) and European Research Council grant ADOR (Advanced Grant 787073). The authors acknowledge the EPSRC Light Element Analysis Facility Grant (EP/T019298/1) and the EPSRC Strategic Equipment Resource Grant (EP/R023751/1).en
dc.description.abstractSince the outbreak of SARS-CoV-2, a multitude of strategies have been explored for the means of protection and shielding against virus particles: filtration equipment (PPE) has been widely used in daily life. In this work, we explore another approach in the form of deactivating coronavirus particles through selective binding onto the surface of metal–organic frameworks (MOFs) to further the fight against the transmission of respiratory viruses. MOFs are attractive materials in this regard, as their rich pore and surface chemistry can easily be modified on demand. The surfaces of three MOFs, UiO-66(Zr), UiO-66-NH2(Zr), and UiO-66-NO2(Zr), have been functionalized with repurposed antiviral agents, namely, folic acid, nystatin, and tenofovir, to enable specific interactions with the external spike protein of the SARS virus. Protein binding studies revealed that this surface modification significantly improved the binding affinity toward glycosylated and non-glycosylated proteins for all three MOFs. Additionally, the pores for the surface-functionalized MOFs can adsorb water, making them suitable for locally dehydrating microbial aerosols. Our findings highlight the immense potential of MOFs in deactivating respiratory coronaviruses to be better equipped to fight future pandemics.
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofACS Applied Materials & Interfacesen
dc.rightsCopyright © 2023 The Authors. Published by American Chemical Society A. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the final published version of the work, which was originally published at https://doi.org/10.1021/acsami.2c21187.en
dc.subjectSARS-CoV-2en
dc.subjectAntiviral drugsen
dc.subjectMetal-organic frameworken
dc.subjectProtein bindingen
dc.subjectWater adsorptionen
dc.subjectQD Chemistryen
dc.subjectQR355 Virologyen
dc.subjectDASen
dc.subjectMCCen
dc.subject.lccQDen
dc.subject.lccQR355en
dc.titleSurface-Functionalized Metal-Organic Frameworks for Binding Coronavirus Proteinsen
dc.typeJournal articleen
dc.contributor.sponsorEuropean Research Councilen
dc.contributor.sponsorEPSRCen
dc.contributor.sponsorEPSRCen
dc.contributor.sponsorScottish Funding Councilen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.identifier.doihttps://doi.org/10.1021/acsami.2c21187
dc.description.statusPeer revieweden
dc.identifier.urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_st-andrews_wos_starter&SrcAuth=WosAPI&KeyUT=WOS:000933969800001&DestLinkType=FullRecord&DestApp=WOSen
dc.identifier.grantnumber787073en
dc.identifier.grantnumberEP/R023751/1en
dc.identifier.grantnumberEP/T019298/1en
dc.identifier.grantnumberN/Aen


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