Surface functionalized metal-organic frameworks for binding coronavirus proteins
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Since the outbreak of SARS-CoV-2, a multitude of strategies have been explored for the means of protection and shielding against virus particles: filtration equipment (PPE) has been widely used in daily life. In this work, we explore another approach in the form of deactivating coronavirus particles through selective binding onto the surface of metal–organic frameworks (MOFs) to further the fight against the transmission of respiratory viruses. MOFs are attractive materials in this regard, as their rich pore and surface chemistry can easily be modified on demand. The surfaces of three MOFs, UiO-66(Zr), UiO-66-NH2(Zr), and UiO-66-NO2(Zr), have been functionalized with repurposed antiviral agents, namely, folic acid, nystatin, and tenofovir, to enable specific interactions with the external spike protein of the SARS virus. Protein binding studies revealed that this surface modification significantly improved the binding affinity toward glycosylated and non-glycosylated proteins for all three MOFs. Additionally, the pores for the surface-functionalized MOFs can adsorb water, making them suitable for locally dehydrating microbial aerosols. Our findings highlight the immense potential of MOFs in deactivating respiratory coronaviruses to be better equipped to fight future pandemics.
Desai , A V , Vornholt , S M , Major , L L , Ettlinger , R , Jansen , C , Rainer , D , de Rome , R , So , V , Wheatley , P S , Edward , A K , Elliott , C , Pramanik , A , Karmakar , A , Armstrong , R , Janiak , C , Smith , T K & Morris , R E 2023 , ' Surface functionalized metal-organic frameworks for binding coronavirus proteins ' , ACS Applied Materials & Interfaces , vol. 15 , no. 7 , pp. 9058–9065 . https://doi.org/10.1021/acsami.2c21187
ACS Applied Materials & Interfaces
Copyright © 2023 The Authors. Published by American Chemical Society A. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the final published version of the work, which was originally published at https://doi.org/10.1021/acsami.2c21187.
DescriptionFunding: This work was supported by University of St Andrews Restarting Research Funding Scheme (SARRF), funded through the SFC grant reference SFC/AN/08/020 (XRR064) and European Research Council grant ADOR (Advanced Grant 787073). The authors acknowledge the EPSRC Light Element Analysis Facility Grant (EP/T019298/1) and the EPSRC Strategic Equipment Resource Grant (EP/R023751/1).
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