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A brainstem integrator for self-location memory and positional homeostasis in zebrafish
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dc.contributor.author | Yang, En | |
dc.contributor.author | Zwart, Maarten F. | |
dc.contributor.author | James, Ben | |
dc.contributor.author | Rubinov, Mikail | |
dc.contributor.author | Wei, Ziqiang | |
dc.contributor.author | Narayan, Sujatha | |
dc.contributor.author | Vladimirov, Nikita | |
dc.contributor.author | Mensh, Brett D. | |
dc.contributor.author | Fitzgerald, James E. | |
dc.contributor.author | Ahrens, Misha B. | |
dc.date.accessioned | 2023-01-05T15:30:10Z | |
dc.date.available | 2023-01-05T15:30:10Z | |
dc.date.issued | 2022-12-22 | |
dc.identifier | 282683822 | |
dc.identifier | c1536317-93f1-43f8-894e-ab2c7bab0f72 | |
dc.identifier | 85144590331 | |
dc.identifier | 000910203600001 | |
dc.identifier.citation | Yang , E , Zwart , M F , James , B , Rubinov , M , Wei , Z , Narayan , S , Vladimirov , N , Mensh , B D , Fitzgerald , J E & Ahrens , M B 2022 , ' A brainstem integrator for self-location memory and positional homeostasis in zebrafish ' , Cell , vol. 185 , no. 26 , e20 , pp. 5011-5027 . https://doi.org/10.1016/j.cell.2022.11.022 | en |
dc.identifier.issn | 0092-8674 | |
dc.identifier.other | RIS: urn:56F539871CE001404EA7541EECBDB73C | |
dc.identifier.other | ORCID: /0000-0002-5073-8631/work/125303058 | |
dc.identifier.uri | https://hdl.handle.net/10023/26685 | |
dc.description | Funding: This work was supported by the Howard Hughes Medical Institute and by the Simons Foundation (Simons Collaboration on the Global Brain #542943SPI). | en |
dc.description.abstract | To track and control self-location, animals integrate their movements through space. Representations of self-location are observed in the mammalian hippocampal formation, but it is unknown if positional representations exist in more ancient brain regions, how they arise from integrated self-motion, and by what pathways they control locomotion. Here, in a head-fixed, fictive-swimming, virtual-reality preparation, we exposed larval zebrafish to a variety of involuntary displacements. They tracked these displacements and, many seconds later, moved toward their earlier location through corrective swimming (“positional homeostasis”). Whole-brain functional imaging revealed a network in the medulla that stores a memory of location and induces an error signal in the inferior olive to drive future corrective swimming. Optogenetically manipulating medullary integrator cells evoked displacement-memory behavior. Ablating them, or downstream olivary neurons, abolished displacement corrections. These results reveal a multiregional hindbrain circuit in vertebrates that integrates self-motion and stores self-location to control locomotor behavior. | |
dc.format.extent | 14263812 | |
dc.language.iso | eng | |
dc.relation.ispartof | Cell | en |
dc.subject | Neuroscience | en |
dc.subject | Memory | en |
dc.subject | Neural circuits | en |
dc.subject | Motor control | en |
dc.subject | Brainstem | en |
dc.subject | Navigation | en |
dc.subject | Path integration | en |
dc.subject | Hippocampus | en |
dc.subject | Zebrafish | en |
dc.subject | Inferior olive | en |
dc.subject | Cerebellum | en |
dc.subject | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | en |
dc.subject | DAS | en |
dc.subject | MCC | en |
dc.subject.lcc | RC0321 | en |
dc.title | A brainstem integrator for self-location memory and positional homeostasis in zebrafish | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Psychology and Neuroscience | en |
dc.contributor.institution | University of St Andrews. Centre for Biophotonics | en |
dc.contributor.institution | University of St Andrews. Institute of Behavioural and Neural Sciences | en |
dc.identifier.doi | https://doi.org/10.1016/j.cell.2022.11.022 | |
dc.description.status | Peer reviewed | en |
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