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dc.contributor.authorYang, En
dc.contributor.authorZwart, Maarten F.
dc.contributor.authorJames, Ben
dc.contributor.authorRubinov, Mikail
dc.contributor.authorWei, Ziqiang
dc.contributor.authorNarayan, Sujatha
dc.contributor.authorVladimirov, Nikita
dc.contributor.authorMensh, Brett D.
dc.contributor.authorFitzgerald, James E.
dc.contributor.authorAhrens, Misha B.
dc.identifier.citationYang , E , Zwart , M F , James , B , Rubinov , M , Wei , Z , Narayan , S , Vladimirov , N , Mensh , B D , Fitzgerald , J E & Ahrens , M B 2022 , ' A brainstem integrator for self-location memory and positional homeostasis in zebrafish ' , Cell , vol. 185 , no. 26 , e20 , pp. 5011-5027 .
dc.identifier.otherPURE: 282683822
dc.identifier.otherPURE UUID: c1536317-93f1-43f8-894e-ab2c7bab0f72
dc.identifier.otherRIS: urn:56F539871CE001404EA7541EECBDB73C
dc.identifier.otherORCID: /0000-0002-5073-8631/work/125303058
dc.identifier.otherScopus: 85144590331
dc.identifier.otherWOS: 000910203600001
dc.descriptionFunding: This work was supported by the Howard Hughes Medical Institute and by the Simons Foundation (Simons Collaboration on the Global Brain #542943SPI).en
dc.description.abstractTo track and control self-location, animals integrate their movements through space. Representations of self-location are observed in the mammalian hippocampal formation, but it is unknown if positional representations exist in more ancient brain regions, how they arise from integrated self-motion, and by what pathways they control locomotion. Here, in a head-fixed, fictive-swimming, virtual-reality preparation, we exposed larval zebrafish to a variety of involuntary displacements. They tracked these displacements and, many seconds later, moved toward their earlier location through corrective swimming (“positional homeostasis”). Whole-brain functional imaging revealed a network in the medulla that stores a memory of location and induces an error signal in the inferior olive to drive future corrective swimming. Optogenetically manipulating medullary integrator cells evoked displacement-memory behavior. Ablating them, or downstream olivary neurons, abolished displacement corrections. These results reveal a multiregional hindbrain circuit in vertebrates that integrates self-motion and stores self-location to control locomotor behavior.
dc.rightsCopyright © 2022 The Authors. This is an open access article under the CC BY license (
dc.subjectNeural circuitsen
dc.subjectMotor controlen
dc.subjectPath integrationen
dc.subjectInferior oliveen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.titleA brainstem integrator for self-location memory and positional homeostasis in zebrafishen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews. Centre for Biophotonicsen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.description.statusPeer revieweden

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