A brainstem integrator for self-location memory and positional homeostasis in zebrafish
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To track and control self-location, animals integrate their movements through space. Representations of self-location are observed in the mammalian hippocampal formation, but it is unknown if positional representations exist in more ancient brain regions, how they arise from integrated self-motion, and by what pathways they control locomotion. Here, in a head-fixed, fictive-swimming, virtual-reality preparation, we exposed larval zebrafish to a variety of involuntary displacements. They tracked these displacements and, many seconds later, moved toward their earlier location through corrective swimming (“positional homeostasis”). Whole-brain functional imaging revealed a network in the medulla that stores a memory of location and induces an error signal in the inferior olive to drive future corrective swimming. Optogenetically manipulating medullary integrator cells evoked displacement-memory behavior. Ablating them, or downstream olivary neurons, abolished displacement corrections. These results reveal a multiregional hindbrain circuit in vertebrates that integrates self-motion and stores self-location to control locomotor behavior.
Yang , E , Zwart , M F , James , B , Rubinov , M , Wei , Z , Narayan , S , Vladimirov , N , Mensh , B D , Fitzgerald , J E & Ahrens , M B 2022 , ' A brainstem integrator for self-location memory and positional homeostasis in zebrafish ' , Cell , vol. 185 , no. 26 , e20 , pp. 5011-5027 . https://doi.org/10.1016/j.cell.2022.11.022
Copyright © 2022 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
DescriptionFunding: This work was supported by the Howard Hughes Medical Institute and by the Simons Foundation (Simons Collaboration on the Global Brain #542943SPI).
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