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dc.contributor.authorEttlinger, Romy
dc.contributor.authorLächelt, Ulrich
dc.contributor.authorGref, Ruxandra
dc.contributor.authorHorcajada, Patricia
dc.contributor.authorLammers, Twan
dc.contributor.authorSerre, Christian
dc.contributor.authorCouvreur, Patrick
dc.contributor.authorMorris, Russell E
dc.contributor.authorWuttke, Stefan
dc.date.accessioned2023-01-05T00:40:45Z
dc.date.available2023-01-05T00:40:45Z
dc.date.issued2022-01-21
dc.identifier277421388
dc.identifier65a79047-d9b4-4f59-8655-f69b074fcfa7
dc.identifier34985082
dc.identifier000739533800001
dc.identifier85123878299
dc.identifier.citationEttlinger , R , Lächelt , U , Gref , R , Horcajada , P , Lammers , T , Serre , C , Couvreur , P , Morris , R E & Wuttke , S 2022 , ' Toxicity of metal-organic framework nanoparticles : from essential analyses to potential applications ' , Chemical Society Reviews , vol. 2022 , no. 2 , pp. 464-484 . https://doi.org/10.1039/d1cs00918den
dc.identifier.issn0306-0012
dc.identifier.urihttps://hdl.handle.net/10023/26676
dc.descriptionFunding: RE and REM thank the European Research Council for funding under the Advanced Grant 787073. PH acknowledges the Spanish Ramón y Cajal Programme (grant agreement no. 2014-15039) and the Multifunctional Metallodrugs in Diagnosis and Therapy Network (MICIU, RED2018-102471-T).en
dc.description.abstractIn the last two decades, the field of metal-organic frameworks (MOFs) has exploded, and MOF nanoparticles in particular are being investigated with increasing interest for various applications, including gas storage and separation, water harvesting, catalysis, energy conversion and storage, sensing, diagnosis, therapy, and theranostics. To further pave their way into real-world applications, and to push the synthesis of MOF nanoparticles that are 'safe-and-sustainable-by-design', this tutorial review aims to shed light on the importance of a systematic toxicity assessment. After clarifying and working out the most important terms and aspects from the field of nanotoxicity, the current state-of-the-art of in vitro and in vivo toxicity studies of MOF nanoparticles is evaluated. Moreover, the key aspects affecting the toxicity of MOF nanoparticles such as their chemical composition, their physico-chemical properties, including their colloidal and chemical stability, are discussed. We highlight the need of more targeted synthesis of MOF nanoparticles that are 'safe-and-sustainable-by-design', and their tailored hazard assessment in the context of their potential applications in order to tap the full potential of this versatile material class in the future.
dc.format.extent21
dc.format.extent4300859
dc.language.isoeng
dc.relation.ispartofChemical Society Reviewsen
dc.subjectQD Chemistryen
dc.subjectACen
dc.subjectMCCen
dc.subject.lccQDen
dc.titleToxicity of metal-organic framework nanoparticles : from essential analyses to potential applicationsen
dc.typeJournal itemen
dc.contributor.sponsorEuropean Research Councilen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.identifier.doihttps://doi.org/10.1039/d1cs00918d
dc.description.statusPeer revieweden
dc.date.embargoedUntil2023-01-05
dc.identifier.grantnumber787073en


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