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4′-Fluoro-nucleosides and nucleotides : from nucleocidin to an emerging class of therapeutics
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dc.contributor.author | Lowe, Phillip T. | |
dc.contributor.author | O’Hagan, David | |
dc.date.accessioned | 2022-12-12T12:30:14Z | |
dc.date.available | 2022-12-12T12:30:14Z | |
dc.date.issued | 2023-01-07 | |
dc.identifier | 282475507 | |
dc.identifier | 3bbf3ff9-e793-43c4-a204-748a7a6d5ffa | |
dc.identifier | 85143862581 | |
dc.identifier | 000893943200001 | |
dc.identifier.citation | Lowe , P T & O’Hagan , D 2023 , ' 4′-Fluoro-nucleosides and nucleotides : from nucleocidin to an emerging class of therapeutics ' , Chemical Society Reviews , vol. 52 , no. 1 , pp. 248-276 . https://doi.org/10.1039/d2cs00762b | en |
dc.identifier.issn | 0306-0012 | |
dc.identifier.other | Jisc: 765914 | |
dc.identifier.other | publisher-id: d2cs00762b | |
dc.identifier.uri | https://hdl.handle.net/10023/26577 | |
dc.description | Funding: We thank EPSRC for a grant and the EU Horizon 2020 Sinfonia consortia for financial support. | en |
dc.description.abstract | The history and development of 4′-fluoro-nucleosides is discussed in this review. This is a class of nucleosides which have their origin in the discovery of the rare fluorine containing natural product nucleocidin. Nucleocidin contains a fluorine atom located at the 4′-position of its ribose ring. From its early isolation as an unexpected natural product, to its total synthesis and bioactivity assessment, nucleocidin has played a role in inspiring the exploration of 4′-fluoro-nucleosides as a privileged motif for nucleoside-based therapeutics. | |
dc.format.extent | 29 | |
dc.format.extent | 6934489 | |
dc.language.iso | eng | |
dc.relation.ispartof | Chemical Society Reviews | en |
dc.subject | QD Chemistry | en |
dc.subject | AC | en |
dc.subject | MCC | en |
dc.subject.lcc | QD | en |
dc.title | 4′-Fluoro-nucleosides and nucleotides : from nucleocidin to an emerging class of therapeutics | en |
dc.type | Journal item | en |
dc.contributor.sponsor | European Commission | en |
dc.contributor.institution | University of St Andrews. Arctic Research Centre | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Institute of Behavioural and Neural Sciences | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.identifier.doi | 10.1039/d2cs00762b | |
dc.description.status | Peer reviewed | en |
dc.identifier.grantnumber | 814418 | en |
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