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dc.contributor.authorLowe, Phillip T.
dc.contributor.authorO’Hagan, David
dc.date.accessioned2022-12-12T12:30:14Z
dc.date.available2022-12-12T12:30:14Z
dc.date.issued2023-01-07
dc.identifier282475507
dc.identifier3bbf3ff9-e793-43c4-a204-748a7a6d5ffa
dc.identifier85143862581
dc.identifier000893943200001
dc.identifier.citationLowe , P T & O’Hagan , D 2023 , ' 4′-Fluoro-nucleosides and nucleotides : from nucleocidin to an emerging class of therapeutics ' , Chemical Society Reviews , vol. 52 , no. 1 , pp. 248-276 . https://doi.org/10.1039/d2cs00762ben
dc.identifier.issn0306-0012
dc.identifier.otherJisc: 765914
dc.identifier.otherpublisher-id: d2cs00762b
dc.identifier.urihttps://hdl.handle.net/10023/26577
dc.descriptionFunding: We thank EPSRC for a grant and the EU Horizon 2020 Sinfonia consortia for financial support.en
dc.description.abstractThe history and development of 4′-fluoro-nucleosides is discussed in this review. This is a class of nucleosides which have their origin in the discovery of the rare fluorine containing natural product nucleocidin. Nucleocidin contains a fluorine atom located at the 4′-position of its ribose ring. From its early isolation as an unexpected natural product, to its total synthesis and bioactivity assessment, nucleocidin has played a role in inspiring the exploration of 4′-fluoro-nucleosides as a privileged motif for nucleoside-based therapeutics.
dc.format.extent29
dc.format.extent6934489
dc.language.isoeng
dc.relation.ispartofChemical Society Reviewsen
dc.subjectQD Chemistryen
dc.subjectACen
dc.subjectMCCen
dc.subject.lccQDen
dc.title4′-Fluoro-nucleosides and nucleotides : from nucleocidin to an emerging class of therapeuticsen
dc.typeJournal itemen
dc.contributor.sponsorEuropean Commissionen
dc.contributor.institutionUniversity of St Andrews. Arctic Research Centreen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.identifier.doi10.1039/d2cs00762b
dc.description.statusPeer revieweden
dc.identifier.grantnumber814418en


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