4′-Fluoro-nucleosides and nucleotides : from nucleocidin to an emerging class of therapeutics
Abstract
The history and development of 4′-fluoro-nucleosides is discussed in this review. This is a class of nucleosides which have their origin in the discovery of the rare fluorine containing natural product nucleocidin. Nucleocidin contains a fluorine atom located at the 4′-position of its ribose ring. From its early isolation as an unexpected natural product, to its total synthesis and bioactivity assessment, nucleocidin has played a role in inspiring the exploration of 4′-fluoro-nucleosides as a privileged motif for nucleoside-based therapeutics.
Citation
Lowe , P T & O’Hagan , D 2023 , ' 4′-Fluoro-nucleosides and nucleotides : from nucleocidin to an emerging class of therapeutics ' , Chemical Society Reviews , vol. 52 , no. 1 , pp. 248-276 . https://doi.org/10.1039/d2cs00762b
Publication
Chemical Society Reviews
Status
Peer reviewed
ISSN
0306-0012Type
Journal item
Description
Funding: We thank EPSRC for a grant and the EU Horizon 2020 Sinfonia consortia for financial support.Collections
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