Direct Chan–Lam amination and etherification of aryl BMIDA reagents
Abstract
We report the development of a method for the direct Chan–Lam coupling of arylboronic acid N-methyliminodiacetic acid esters (ArBMIDA) with amine and alcohol nucleophiles. A wide range of C–N and C–O cross-coupled products in 34–99% yield (34 examples). This method serves to expand the scope of organoboron components that can be used directly in this oxidative coupling reaction and provides opportunities for streamlining synthesis.
Citation
Halford-McGuff , J , Israel , E M , West , M , Vantourout , J C & Watson , A J B 2022 , ' Direct Chan–Lam amination and etherification of aryl BMIDA reagents ' , European Journal of Organic Chemistry , vol. 2022 , no. 45 , e202200993 . https://doi.org/10.1002/ejoc.202200993
Publication
European Journal of Organic Chemistry
Status
Peer reviewed
ISSN
1434-193XType
Journal article
Description
Funding: Engineering and Physical Sciences Research Council; University of St Andrews; Leverhulme Trust (GrantNumber(s): RF-2022-014).Collections
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