Unexpected triaxial preferences in some all-syn 1,3,5-trifluorocyclohexanes
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Theory and solution NMR indicate that all-syn 1,3,5-trifluorocyclohexane 5 adopts the expected tri-equatorial conformation, however in the solid state the more polar triaxial conformation is observed. This and the favoured conformations of substituted (Me, OMe, NH(CO)Me, NHBoc) derivatives of 5 are investigated to explore triaxial C–F preferences.
Yu , C , Piscelli , B A , Maharik , N A , Cordes , D B , Slawin , A M Z , Cormanich , R A & O'Hagan , D 2022 , ' Unexpected triaxial preferences in some all- syn 1,3,5-trifluorocyclohexanes ' , Chemical Communications , vol. Advance Article . https://doi.org/10.1039/D2CC05058G
Copyright © The Author(s) 2022. Open Access Article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
DescriptionAuthors thank the Chinese Scholarship Council and FAPESP for studentships (BAP, #2021/09716-5) a Young Researcher Award (RAC, #2018/03910-1) and FAEPEX for a fellowship (RAC, #2479/21).
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