Cadmium(II) Schiff base complex containing 5-fluoroisatin moiety : synthesis, characterization, antibacterial activity and structural studies
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The Schiff base ligand, HSB5FISA ( H1 ), obtained by the condensation of S-benzyldithiocarbazate with 5-fluoroisatin, has been employed to synthesize a new cadmium(II) complex, Cd(SB5FISA)2 ( 2 ) (SB5FISA = monoanionic form of H1 ). The complex has been characterized by elemental analysis, molar conductivity, magnetic susceptibility, inductively coupled plasma atomic emission spectroscopy (ICP-AES), Fourier-transform infrared spectroscopy (FT-IR) and ultraviolet-visible spectroscopy (UV-Vis). The crystallographic study of Cd(SB5FISA)2•2DMSO ( 2a ) (DMSO = dimethyl sulfoxide) was conducted using single-crystal X-ray diffraction. The crystal structure of 2a confirmed the presence of six-coordinated cadmium in a distorted octahedral environment. Ligand H1 behaves in a tridentate monoanionic fashion, coordinating to a cadmium(II) metal centre through the thiolate sulfur, azomethine nitrogen and carbonyl oxygen. The antibacterial activity of both H1 and 2 was examined against four different bacterial strains using the disc diffusion method. Complex 2 showed significant inhibitory effect against Bacillus subtilis with an inhibition zone of 14 mm, comparable to the standard antibiotic streptomycin.
Abdul Manan , M A F & Cordes , D B 2022 , ' Cadmium(II) Schiff base complex containing 5-fluoroisatin moiety : synthesis, characterization, antibacterial activity and structural studies ' , Trends in Sciences , vol. 19 , no. 18 , 5796 . https://doi.org/10.48048/tis.2022.5796
Trends in Sciences
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DescriptionFunding: Financial support is acknowledged from Universiti Teknologi MARA.
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