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dc.contributor.authorMelendez-Celis, U
dc.contributor.authorSpezzia-Mazzocco, T
dc.contributor.authorPersheyev, Saydulla
dc.contributor.authorLian, Cheng
dc.contributor.authorSamuel, Ifor David William
dc.contributor.authorRamirez-San Juan, J
dc.contributor.authorRamos-Garcia, R
dc.date.accessioned2022-10-02T23:36:12Z
dc.date.available2022-10-02T23:36:12Z
dc.date.issued2021-10-03
dc.identifier276151808
dc.identifier22ab73aa-8c3a-4533-b10b-02b19fa7d0dd
dc.identifier85117786547
dc.identifier000716919200002
dc.identifier.citationMelendez-Celis , U , Spezzia-Mazzocco , T , Persheyev , S , Lian , C , Samuel , I D W , Ramirez-San Juan , J & Ramos-Garcia , R 2021 , ' Organic light emitting diode for in vitro antimicrobial photodynamic therapy of Candida strains ' , Photodiagnosis and Photodynamic Therapy , vol. In Press , 102567 . https://doi.org/10.1016/j.pdpdt.2021.102567en
dc.identifier.issn1572-1000
dc.identifier.urihttps://hdl.handle.net/10023/26120
dc.descriptionFunding: NSF grant 1545852 (OISE:PIRE-SOMBRERO)/CONACyT 251992.en
dc.description.abstractOrganic light emitting diodes (OLEDs) are very attractive light sources because they are large area emitters and, can in principle, deposited on flexible substrates. These features make them suitable for ambulatory photodynamic therapy (PDT), in fact there are a few reports of in vitro or in vivo OLED based PDT studies for cancer or microbial inhibition but to our best knowledge, none against yeasts. Yeast infections are a significant health risk, especially in low income countries with limited medical facilities. In this work, OLED-based antimicrobial PDT (aPDT), using methylene blue (MB) as photosensitizer (PS), is studied to inactivate opportunistic yeast of four Candida strains of two species: Candida albicans and Candida tropicalis. Before aPDT experiments, fluconazole-resistance was evaluated for all strains, showing that both strains of C. tropicalis were resistant and both strains of C. albicans were sensitive to it. We found that is useful for aPDT and that 3 repetitive irradiations work better than a single dose while keeping the total fluence constant, and that this result applies whether or not the strains are resistant to fluconazole.
dc.format.extent1119942
dc.language.isoeng
dc.relation.ispartofPhotodiagnosis and Photodynamic Therapyen
dc.subjectOLEDen
dc.subjectPhotodynamic therapyen
dc.subjectCandidaen
dc.subjectMethylene blueen
dc.subjectIn vitroen
dc.subjectQC Physicsen
dc.subjectQH301 Biologyen
dc.subjectRM Therapeutics. Pharmacologyen
dc.subjectDASen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccQCen
dc.subject.lccQH301en
dc.subject.lccRMen
dc.titleOrganic light emitting diode for in vitro antimicrobial photodynamic therapy of Candida strainsen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.contributor.institutionUniversity of St Andrews. Centre for Biophotonicsen
dc.contributor.institutionUniversity of St Andrews. Condensed Matter Physicsen
dc.identifier.doi10.1016/j.pdpdt.2021.102567
dc.description.statusPeer revieweden
dc.date.embargoedUntil2022-10-03


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