Organic light emitting diode for in vitro antimicrobial photodynamic therapy of Candida strains
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Organic light emitting diodes (OLEDs) are very attractive light sources because they are large area emitters and, can in principle, deposited on flexible substrates. These features make them suitable for ambulatory photodynamic therapy (PDT), in fact there are a few reports of in vitro or in vivo OLED based PDT studies for cancer or microbial inhibition but to our best knowledge, none against yeasts. Yeast infections are a significant health risk, especially in low income countries with limited medical facilities. In this work, OLED-based antimicrobial PDT (aPDT), using methylene blue (MB) as photosensitizer (PS), is studied to inactivate opportunistic yeast of four Candida strains of two species: Candida albicans and Candida tropicalis. Before aPDT experiments, fluconazole-resistance was evaluated for all strains, showing that both strains of C. tropicalis were resistant and both strains of C. albicans were sensitive to it. We found that is useful for aPDT and that 3 repetitive irradiations work better than a single dose while keeping the total fluence constant, and that this result applies whether or not the strains are resistant to fluconazole.
Melendez-Celis , U , Spezzia-Mazzocco , T , Persheyev , S , Lian , C , Samuel , I D W , Ramirez-San Juan , J & Ramos-Garcia , R 2021 , ' Organic light emitting diode for in vitro antimicrobial photodynamic therapy of Candida strains ' , Photodiagnosis and Photodynamic Therapy , vol. In Press , 102567 . https://doi.org/10.1016/j.pdpdt.2021.102567
Photodiagnosis and Photodynamic Therapy
Copyright © 2021 Published by Elsevier B.V. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.pdpdt.2021.102567.
DescriptionFunding: NSF grant 1545852 (OISE:PIRE-SOMBRERO)/CONACyT 251992.
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