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Vaccine effectiveness against symptomatic SARS-CoV-2 infection in adults aged 65 years and older in primary care : I-MOVE-COVID-19 project, Europe, December 2020 to May 2021

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Date
22/07/2021
Author
Kissling, Esther
Hooiveld, Mariette
Sandonis Martín, Virginia
Martínez-Baz, Iván
William, Naoma
Vilcu, Ana Maria
Mazagatos, Clara
Domegan, Lisa
de Lusignan, Simon
Meijer, Adam
Machado, Ausenda
Brytting, Mia
Casado, Itziar
Murray, Josephine L.K.
Belhillil, Sylvie
Larrauri, Amparo
O'Donnell, Joan
Tsang, Ruby
de Lange, Marit
Rodrigues, Ana Paula
Riess, Maximilian
Castilla, Jesús
Hamilton, Mark
Falchi, Alessandra
Pozo, Francisco
Dunford, Linda
Cogdale, Jade
Jansen, Tessa
Guiomar, Raquel
Enkirch, Theresa
Burgui, Cristina
Sigerson, Debbie
Blanchon, Thierry
Martínez Ochoa, Eva María
Connell, Jeff
Ellis, Joanna
van Gageldonk-Lafeber, Rianne
Kislaya, Irina
Rose, Angela MC
Valenciano, Marta
I-MOVE-COVID-19 primary care study team
Keywords
COVID-19
Europe
Multicentre study
SARS-CoV-2
Test-negative design
Vaccine effectiveness
QR355 Virology
RA0421 Public health. Hygiene. Preventive Medicine
RM Therapeutics. Pharmacology
Virology
Epidemiology
Public Health, Environmental and Occupational Health
3rd-DAS
NIS
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Abstract
We measured COVID-19 vaccine effectiveness (VE) against symptomatic SARS-CoV-2 infection at primary care/outpatient level among adults ≥ 65 years old using a multicentre test-negative design in eight European countries. We included 592 SARS-CoV-2 cases and 4,372 test-negative controls in the main analysis. The VE was 62% (95% CI: 45-74) for one dose only and 89% (95% CI: 79-94) for complete vaccination. COVID-19 vaccines provide good protection against COVID-19 presentation at primary care/outpatient level, particularly among fully vaccinated individuals.
Citation
Kissling , E , Hooiveld , M , Sandonis Martín , V , Martínez-Baz , I , William , N , Vilcu , A M , Mazagatos , C , Domegan , L , de Lusignan , S , Meijer , A , Machado , A , Brytting , M , Casado , I , Murray , J L K , Belhillil , S , Larrauri , A , O'Donnell , J , Tsang , R , de Lange , M , Rodrigues , A P , Riess , M , Castilla , J , Hamilton , M , Falchi , A , Pozo , F , Dunford , L , Cogdale , J , Jansen , T , Guiomar , R , Enkirch , T , Burgui , C , Sigerson , D , Blanchon , T , Martínez Ochoa , E M , Connell , J , Ellis , J , van Gageldonk-Lafeber , R , Kislaya , I , Rose , A MC , Valenciano , M & I-MOVE-COVID-19 primary care study team 2021 , ' Vaccine effectiveness against symptomatic SARS-CoV-2 infection in adults aged 65 years and older in primary care : I-MOVE-COVID-19 project, Europe, December 2020 to May 2021 ' , Eurosurveillance , vol. 26 , no. 29 , 2100670 . https://doi.org/10.2807/1560-7917.ES.2021.26.29.2100670
Publication
Eurosurveillance
Status
Peer reviewed
DOI
https://doi.org/10.2807/1560-7917.ES.2021.26.29.2100670
ISSN
1025-496X
Type
Journal article
Rights
This article is copyright of the authors or their affiliated institutions, 2021. This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence and indicate if changes were made.
Description
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101003673.
Collections
  • University of St Andrews Research
URI
http://hdl.handle.net/10023/26062

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