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dc.contributor.authorBalslev, Daniela
dc.contributor.authorMitchell, Alexandra G.
dc.contributor.authorFaria, Patrick J.M.
dc.contributor.authorPriba, Lukasz
dc.contributor.authorMacfarlane, Jennifer A.
dc.date.accessioned2022-09-22T15:30:24Z
dc.date.available2022-09-22T15:30:24Z
dc.date.issued2022-09-22
dc.identifier.citationBalslev , D , Mitchell , A G , Faria , P J M , Priba , L & Macfarlane , J A 2022 , ' Proprioceptive contribution to oculomotor control in humans ' , Human Brain Mapping , vol. Early View , 26080 . https://doi.org/10.1002/hbm.26080en
dc.identifier.issn1065-9471
dc.identifier.otherPURE: 280993488
dc.identifier.otherPURE UUID: 27f79d56-53e1-4373-a0f7-440b44ba4f83
dc.identifier.otherORCID: /0000-0001-7843-1044/work/119628133
dc.identifier.urihttp://hdl.handle.net/10023/26058
dc.descriptionThis work was supported by an award from the Wellcome Trust Institutional Strategic Support Fund at the University of St Andrews, grant code 204821/Z/16/Z (DB).en
dc.description.abstractStretch receptors in the extraocular muscles (EOMs) inform the central nervous system about the rotation of one's own eyes in the orbits. Whereas fine control of the skeletal muscles hinges critically on proprioceptive feedback, the role of proprioception in oculomotor control remains unclear. Human behavioural studies provide evidence for EOM proprioception in oculomotor control, however, behavioural and electrophysiological studies in the macaque do not. Unlike macaques, humans possess numerous muscle spindles in their EOMs. To find out whether the human oculomotor nuclei respond to proprioceptive feedback we used functional magnetic resonance imaging (fMRI). With their eyes closed, participants placed their right index finger on the eyelid at the outer corner of the right eye. When prompted by a sound, they pushed the eyeball gently and briefly towards the nose. Control conditions separated out motor and tactile task components. The stretch of the right lateral rectus muscle was associated with activation of the left oculomotor nucleus and subthreshold activation of the left abducens nucleus. Because these nuclei control the horizontal movements of the left eye, we hypothesized that proprioceptive stimulation of the right EOM triggered left eye movement. To test this, we followed up with an eye-tracking experiment in complete darkness using the same behavioural task as in the fMRI study. The left eye moved actively in the direction of the passive displacement of the right eye, albeit with a smaller amplitude. Eye tracking corroborated neuroimaging findings to suggest a proprioceptive contribution to ocular alignment.
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofHuman Brain Mappingen
dc.rightsCopyright © 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectVisualen
dc.subjectEyeen
dc.subjectHumanen
dc.subjectExtraocular musclesen
dc.subjectProprioceptiveen
dc.subjectOculomotoren
dc.subjectQP Physiologyen
dc.subjectDASen
dc.subject.lccQPen
dc.titleProprioceptive contribution to oculomotor control in humansen
dc.typeJournal articleen
dc.contributor.sponsorThe Wellcome Trusten
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.identifier.doihttps://doi.org/10.1002/hbm.26080
dc.description.statusPeer revieweden
dc.identifier.grantnumber204821/Z/16/Zen


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