Proprioceptive contribution to oculomotor control in humans
MetadataShow full item record
Altmetrics Handle Statistics
Altmetrics DOI Statistics
Stretch receptors in the extraocular muscles (EOMs) inform the central nervous system about the rotation of one's own eyes in the orbits. Whereas fine control of the skeletal muscles hinges critically on proprioceptive feedback, the role of proprioception in oculomotor control remains unclear. Human behavioural studies provide evidence for EOM proprioception in oculomotor control, however, behavioural and electrophysiological studies in the macaque do not. Unlike macaques, humans possess numerous muscle spindles in their EOMs. To find out whether the human oculomotor nuclei respond to proprioceptive feedback we used functional magnetic resonance imaging (fMRI). With their eyes closed, participants placed their right index finger on the eyelid at the outer corner of the right eye. When prompted by a sound, they pushed the eyeball gently and briefly towards the nose. Control conditions separated out motor and tactile task components. The stretch of the right lateral rectus muscle was associated with activation of the left oculomotor nucleus and subthreshold activation of the left abducens nucleus. Because these nuclei control the horizontal movements of the left eye, we hypothesized that proprioceptive stimulation of the right EOM triggered left eye movement. To test this, we followed up with an eye-tracking experiment in complete darkness using the same behavioural task as in the fMRI study. The left eye moved actively in the direction of the passive displacement of the right eye, albeit with a smaller amplitude. Eye tracking corroborated neuroimaging findings to suggest a proprioceptive contribution to ocular alignment.
Balslev , D , Mitchell , A G , Faria , P J M , Priba , L & Macfarlane , J A 2022 , ' Proprioceptive contribution to oculomotor control in humans ' , Human Brain Mapping , vol. 43 , no. 16 , 26080 , pp. 5081-5090 . https://doi.org/10.1002/hbm.26080
Human Brain Mapping
Copyright © 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
DescriptionThis work was supported by an award from the Wellcome Trust Institutional Strategic Support Fund at the University of St Andrews, grant code 204821/Z/16/Z (DB).
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.