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dc.contributor.authorHillebrandt, Sabina
dc.contributor.authorKeum, Changmin
dc.contributor.authorDeng, Yali
dc.contributor.authorChavas, Joël
dc.contributor.authorGalle, Charlie
dc.contributor.authorHardin, Thomas
dc.contributor.authorGalluppi, Francesco
dc.contributor.authorGather, Malte Christian
dc.date.accessioned2022-08-29T15:30:11Z
dc.date.available2022-08-29T15:30:11Z
dc.date.issued2022-08-28
dc.identifier.citationHillebrandt , S , Keum , C , Deng , Y , Chavas , J , Galle , C , Hardin , T , Galluppi , F & Gather , M C 2022 , ' High brightness, highly directional organic light-emitting diodes as light sources for future light-amplifying prosthetics in the optogenetic management of vision loss ' , Advanced Optical Materials , vol. Early View , 2200877 . https://doi.org/10.1002/adom.202200877en
dc.identifier.issn2195-1071
dc.identifier.otherPURE: 280796969
dc.identifier.otherPURE UUID: 0305170e-d91a-4ec4-aee2-c9ce2f967d8d
dc.identifier.otherORCID: /0000-0002-4857-5562/work/118411920
dc.identifier.otherScopus: 85136865081
dc.identifier.otherWOS: 000846682000001
dc.identifier.urihttp://hdl.handle.net/10023/25908
dc.descriptionFunding: Engineering and Physical Sciences Research Council (Grant Number(s): EP/R010595/1). National Science Foundation (Grant Number(s): 1706207). Defense Sciences Office, DARPA (Grant Number(s): N66001-17-C-4012). Leverhulme Trust (Grant Number(s): RPG-2017-231). Alexander von Humboldt-Stiftung (Grant Number(s): Humboldt Professur). National Research Foundation of Korea (GrantNumber(s): 2017R1A6A3A03012331). China Sponsorship Council.en
dc.description.abstractOptogenetic control of retinal cells transduced with light-sensitive channelrhodopsins can enable restoration of visual perception in patients with vision loss. However, a light intensity orders of magnitude higher than ambient light conditions is required to achieve robust cell activation. Relatively bulky wearable light amplifiers are currently used to deliver sufficient photon flux (>1016 photons/cm2/s in a ±10° emission cone) at a suitable wavelength (e.g., 600 nm for channelrhodopsin ChrimsonR). Here, ultrahigh brightness organic light-emitting diodes (OLEDs) with highly directional emission are developed, with the ultimate aim of providing high-resolution optogenetic control of thousands of retinal cells in parallel from a compact device. The orange-emitting phosphorescent OLEDs use doped charge transport layers, generate narrowband emission peaking at 600 nm, and achieve a luminance of 684 000 cd m–2 at 15 V forward bias. In addition, tandem-stack OLEDs with a luminance of 1 152 000 cd m–2 and doubled quantum efficiency are demonstrated, which greatly reduces electrical and thermal stress in these devices. At the photon flux required to trigger robust neuron firing in genetically modified retinal cells and when using heat sinking and realistic duty cycles (20% at 12.5 Hz), the tandem-stack OLEDs therefore show a greatly improved half-brightness lifetime of 800 h.
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofAdvanced Optical Materialsen
dc.rightsCopyright © 2022 The Authors. Advanced Optical Materials published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectChannelrhodopsinsen
dc.subjectNeurophotonicsen
dc.subjectOrganic electronicsen
dc.subjectPhotostimulationen
dc.subjectRetinitis pigmentosaen
dc.subjectQC Physicsen
dc.subjectDASen
dc.subject.lccQCen
dc.titleHigh brightness, highly directional organic light-emitting diodes as light sources for future light-amplifying prosthetics in the optogenetic management of vision lossen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews. Centre for Biophotonicsen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1002/adom.202200877
dc.description.statusPeer revieweden


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