Challenges in predicting the change in the cumulative exposure of new tobacco and related products based on emissions and toxicity dose–response data
Abstract
Many novel tobacco products have been developed in recent years. Although many may emit lower levels of several toxicants, their risk in the long term remains unclear. We previously published a method for the exposure assessment of mixtures that can be used to compare the changes in cumulative exposure to carcinogens among tobacco products. While further developing this method by including more carcinogens or to explore its application to non-cancer endpoints, we encountered a lack of data that are required for better-substantiated conclusions regarding differences in exposure between products. In this special communication, we argue the case for more data on adverse health effects, as well as more data on the composition of the emissions from tobacco products. Such information can be used to identify significant changes in relevance to health using the cumulative exposure method with different products and to substantiate regulatory decisions.
Citation
Staal , Y C M , Bil , W , Bokkers , B G H , Soeteman-Hernández , L G , Stephens , W E & Talhout , R 2022 , ' Challenges in predicting the change in the cumulative exposure of new tobacco and related products based on emissions and toxicity dose–response data ' , International Journal of Environmental Research and Public Health , vol. 19 , no. 17 , 10528 . https://doi.org/10.3390/ijerph191710528
Publication
International Journal of Environmental Research and Public Health
Status
Peer reviewed
ISSN
1660-4601Type
Journal article
Description
Funding: This work was funded by the Netherlands Food and Consumer Product Safety Authority (NVWA), Utrecht, the Netherlands. Project number 9.7.1Collections
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