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Tuberculosis Molecular Bacterial Load Assay reveals early delayed bacterial killing in patients with relapse

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dc.contributor.authorNtinginya, Nyanda Elias
dc.contributor.authorBakuli, Abishek
dc.contributor.authorMapamba, Daniel
dc.contributor.authorSabiiti, Wilber
dc.contributor.authorKibiki, Gibson
dc.contributor.authorMinja, Lilian Tina
dc.contributor.authorKuchaka, Davis
dc.contributor.authorReither, Klaus
dc.contributor.authorPhillips, Patrick
dc.contributor.authorBoeree, Martin J
dc.contributor.authorGillespie, Stephen Henry
dc.contributor.authorHoelscher, Michael
dc.contributor.authorHeinrich, Norbert
dc.contributor.authorPanACEA Consortium
dc.date.accessioned2022-07-28T10:30:14Z
dc.date.available2022-07-28T10:30:14Z
dc.date.issued2023-02-01
dc.identifier280147052
dc.identifier14f76917-5a5d-4270-9fdf-b0106da8eb40
dc.identifier000826596100001
dc.identifier85147783549
dc.identifier.citationNtinginya , N E , Bakuli , A , Mapamba , D , Sabiiti , W , Kibiki , G , Minja , L T , Kuchaka , D , Reither , K , Phillips , P , Boeree , M J , Gillespie , S H , Hoelscher , M , Heinrich , N & PanACEA Consortium 2023 , ' Tuberculosis Molecular Bacterial Load Assay reveals early delayed bacterial killing in patients with relapse ' , Clinical Infectious Diseases , vol. 76 , no. 3 , ciac445 , pp. e990-e994 . https://doi.org/10.1093/cid/ciac445en
dc.identifier.issn1058-4838
dc.identifier.otherORCID: /0000-0001-6537-7712/work/116597958
dc.identifier.otherORCID: /0000-0002-4742-2791/work/116598341
dc.identifier.urihttps://hdl.handle.net/10023/25735
dc.descriptionFunding: this work was supported by several funding agencies. The PanACEA MAMS study was funded by the European and Developing Countries Clinical Trials Partnership (EDCTP1); Grant No. IP.2007.32011.013, IP.2007.32011.012, and IP.2007.32011.011 as well as by the German Ministry of Education and Research (01KA0901). This analysis was funded by the German Center for Infection Research (DZIF); grant no. 02.702.en
dc.description.abstractBacterial killing in patients with tuberculosis (TB) relapse was compared to that in patients achieving cure, measured by TB molecular bacterial load assay (TB-MBLA) or mycobacteria growth indicator tube (MGIT) time to positivity (TTP). TB-MBLA in 4 relapsed patients was significantly different compared to 132 cured patients after 2 weeks of treatment; MGIT TTP showed a significant difference from week 8.
dc.format.extent5
dc.format.extent454744
dc.language.isoeng
dc.relation.ispartofClinical Infectious Diseasesen
dc.subjectTuberculosisen
dc.subjectBiomarkeren
dc.subjectRelapseen
dc.subjectClinical trialen
dc.subjectQR Microbiologyen
dc.subjectNDASen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectMCCen
dc.subject.lccQRen
dc.titleTuberculosis Molecular Bacterial Load Assay reveals early delayed bacterial killing in patients with relapseen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. Infection and Global Health Divisionen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews. Centre for Biophotonicsen
dc.contributor.institutionUniversity of St Andrews. Global Health Implementation Groupen
dc.contributor.institutionUniversity of St Andrews. Gillespie Groupen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doi10.1093/cid/ciac445
dc.description.statusPeer revieweden


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