Tuberculosis Molecular Bacterial Load Assay reveals early delayed bacterial killing in patients with relapse
Abstract
Bacterial killing in patients with tuberculosis (TB) relapse was compared to that in patients achieving cure, measured by TB molecular bacterial load assay (TB-MBLA) or mycobacteria growth indicator tube (MGIT) time to positivity (TTP). TB-MBLA in 4 relapsed patients was significantly different compared to 132 cured patients after 2 weeks of treatment; MGIT TTP showed a significant difference from week 8.
Citation
Ntinginya , N E , Bakuli , A , Mapamba , D , Sabiiti , W , Kibiki , G , Minja , L T , Kuchaka , D , Reither , K , Phillips , P , Boeree , M J , Gillespie , S H , Hoelscher , M , Heinrich , N & PanACEA Consortium 2023 , ' Tuberculosis Molecular Bacterial Load Assay reveals early delayed bacterial killing in patients with relapse ' , Clinical Infectious Diseases , vol. 76 , no. 3 , ciac445 , pp. e990-e994 . https://doi.org/10.1093/cid/ciac445
Publication
Clinical Infectious Diseases
Status
Peer reviewed
ISSN
1058-4838Type
Journal article
Description
Funding: this work was supported by several funding agencies. The PanACEA MAMS study was funded by the European and Developing Countries Clinical Trials Partnership (EDCTP1); Grant No. IP.2007.32011.013, IP.2007.32011.012, and IP.2007.32011.011 as well as by the German Ministry of Education and Research (01KA0901). This analysis was funded by the German Center for Infection Research (DZIF); grant no. 02.702.Collections
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