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dc.contributor.authorRezapour, Tara
dc.contributor.authorHatami, Javad
dc.contributor.authorFarhoudian, Ali
dc.contributor.authorNoroozi, Alireza
dc.contributor.authorDaneshmand, Reza
dc.contributor.authorSofuoglu, Mehmet
dc.contributor.authorBaldacchino, Alex
dc.contributor.authorEkhtiari, Hamed
dc.identifier.citationRezapour , T , Hatami , J , Farhoudian , A , Noroozi , A , Daneshmand , R , Sofuoglu , M , Baldacchino , A & Ekhtiari , H 2021 , ' Baseline executive functions and receiving cognitive rehabilitation can predict treatment response in people with opioid use disorder ' , Journal of Substance Abuse Treatment .
dc.identifier.otherRIS: urn:FC8FC997FEEC0C86AEEFAAD9456BE770
dc.identifier.otherORCID: /0000-0002-5388-7376/work/97129789
dc.descriptionTR and AF have received supports from the Cognitive Science and Technologies Council (CSTC) of Iran and Tehran University of Medical Sciences (TUMS) for the ongoing Clinical Trial with NECOREDA.en
dc.description.abstractBackground Impaired cognitive functions, particularly executive function, predicts poor treatment success in people with substance use disorders. The current study investigated the effect of receiving adjunct cognitive rehabilitation and baseline executive function (EF) measures on treatment response among people with opioid use disorder (OUD). Method The analysis sample consisted of 113 participants with OUD who were discharged from a compulsory court-mandated methadone maintenance treatment (MMT) and followed for 3 months. We used the Backward digit span/Auditory verbal learning, Stroop, and Trail making tests to assess the three measures of EF, including working memory, inhibition, and shifting, respectively. Treatment response was operationalized as (1) treatment retention and (2) the number of positive urine tests for morphine during 3-month follow-up periods. The study used Cox's proportional hazards model and linear mixed model to identify predictive factors. Results Lower Stroop interference scores predicted increased length of stay in treatment (χ2 = 33.15, P < 0.001). The linear mixed model showed that scores on auditory verbal learning test and group intervention predicted the number of positive urine tests during a 3-month follow-up. Conclusion Working memory and inhibitory control, as well as receiving cognitive rehabilitation, could be potentially considered as predictors of treatment response for newly MMT admitted patients with OUD. Assessment of EF before treatment initiation may inform treatment providers about patient's cognitive deficits that may interfere with therapeutic interventions.
dc.relation.ispartofJournal of Substance Abuse Treatmenten
dc.subjectExecutive functionen
dc.subjectTreatment responseen
dc.subjectOpioid use disordersen
dc.subjectCognitive rehabilitationen
dc.subjectMethadone maintenance treatmenten
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.titleBaseline executive functions and receiving cognitive rehabilitation can predict treatment response in people with opioid use disorderen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. Population and Behavioural Science Divisionen
dc.contributor.institutionUniversity of St Andrews. Centre for Minorities Research (CMR)en
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.description.statusPeer revieweden

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