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Baseline executive functions and receiving cognitive rehabilitation can predict treatment response in people with opioid use disorder

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Rezapour_2021_Baseline_executive_functions_JOSAT_AAM.pdf (1.902Mb)
Date
07/07/2021
Author
Rezapour, Tara
Hatami, Javad
Farhoudian, Ali
Noroozi, Alireza
Daneshmand, Reza
Sofuoglu, Mehmet
Baldacchino, Alex
Ekhtiari, Hamed
Keywords
Executive function
Treatment response
Opioid use disorders
Cognitive rehabilitation
Retention
Relapse
Methadone maintenance treatment
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
NDAS
AC
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Abstract
Background Impaired cognitive functions, particularly executive function, predicts poor treatment success in people with substance use disorders. The current study investigated the effect of receiving adjunct cognitive rehabilitation and baseline executive function (EF) measures on treatment response among people with opioid use disorder (OUD). Method The analysis sample consisted of 113 participants with OUD who were discharged from a compulsory court-mandated methadone maintenance treatment (MMT) and followed for 3 months. We used the Backward digit span/Auditory verbal learning, Stroop, and Trail making tests to assess the three measures of EF, including working memory, inhibition, and shifting, respectively. Treatment response was operationalized as (1) treatment retention and (2) the number of positive urine tests for morphine during 3-month follow-up periods. The study used Cox's proportional hazards model and linear mixed model to identify predictive factors. Results Lower Stroop interference scores predicted increased length of stay in treatment (χ2 = 33.15, P < 0.001). The linear mixed model showed that scores on auditory verbal learning test and group intervention predicted the number of positive urine tests during a 3-month follow-up. Conclusion Working memory and inhibitory control, as well as receiving cognitive rehabilitation, could be potentially considered as predictors of treatment response for newly MMT admitted patients with OUD. Assessment of EF before treatment initiation may inform treatment providers about patient's cognitive deficits that may interfere with therapeutic interventions.
Citation
Rezapour , T , Hatami , J , Farhoudian , A , Noroozi , A , Daneshmand , R , Sofuoglu , M , Baldacchino , A & Ekhtiari , H 2021 , ' Baseline executive functions and receiving cognitive rehabilitation can predict treatment response in people with opioid use disorder ' , Journal of Substance Abuse Treatment . https://doi.org/10.1016/j.jsat.2021.108558
Publication
Journal of Substance Abuse Treatment
Status
Peer reviewed
DOI
https://doi.org/10.1016/j.jsat.2021.108558
ISSN
0740-5472
Type
Journal article
Rights
Copyright © 2021 Elsevier Inc. All rights reserved. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.jsat.2021.108558.
Description
TR and AF have received supports from the Cognitive Science and Technologies Council (CSTC) of Iran and Tehran University of Medical Sciences (TUMS) for the ongoing Clinical Trial with NECOREDA.
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/25615

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