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Albumin-mediated extracellular zinc speciation drives cellular zinc uptake

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dc.contributor.authorCoverdale, James P. C.
dc.contributor.authorvan den Berg, Hugo A.
dc.contributor.authorKhazaipoul, Siavash
dc.contributor.authorBridgewater, Hannah E.
dc.contributor.authorStewart, Alan J.
dc.contributor.authorBlindauer, Claudia A.
dc.date.accessioned2022-06-15T12:30:06Z
dc.date.available2022-06-15T12:30:06Z
dc.date.issued2022-07-07
dc.identifier.citationCoverdale , J P C , van den Berg , H A , Khazaipoul , S , Bridgewater , H E , Stewart , A J & Blindauer , C A 2022 , ' Albumin-mediated extracellular zinc speciation drives cellular zinc uptake ' , Chemical Communications , vol. 58 , no. 53 , pp. 7384-7387 . https://doi.org/10.1039/D2CC02278Hen
dc.identifier.issn1359-7345
dc.identifier.otherPURE: 279750462
dc.identifier.otherPURE UUID: 072f016d-c1cb-44b8-8fe9-1af514b607d6
dc.identifier.otherORCID: /0000-0003-4580-1840/work/114641504
dc.identifier.otherScopus: 85132239507
dc.identifier.otherWOS: 000810074000001
dc.identifier.urihttps://hdl.handle.net/10023/25536
dc.descriptionThis work was financially supported by the Leverhulme Trust (RPG-2017-214) and BBSRC (BB/J006467/1 and BB/V014684/1). We thank Prof. Andrew Riches (University of St. Andrews) for provision of materials, and Dr. Elizabeth Bolitho (University of Warwick) for assistance with cell culture experiments.en
dc.description.abstractThe role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.
dc.format.extent4
dc.language.isoeng
dc.relation.ispartofChemical Communicationsen
dc.rightsCopyright © The Author(s). Open Access. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.en
dc.subjectQD Chemistryen
dc.subjectQH301 Biologyen
dc.subjectNDASen
dc.subject.lccQDen
dc.subject.lccQH301en
dc.titleAlbumin-mediated extracellular zinc speciation drives cellular zinc uptakeen
dc.typeJournal articleen
dc.contributor.sponsorBBSRCen
dc.contributor.sponsorThe Leverhulme Trusten
dc.contributor.sponsorBBSRCen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews. Cellular Medicine Divisionen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.identifier.doihttps://doi.org/10.1039/D2CC02278H
dc.description.statusPeer revieweden
dc.identifier.grantnumberBB/J006467/1en
dc.identifier.grantnumberRPG-2017-214en
dc.identifier.grantnumberBB/V014684/1en


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