Albumin-mediated extracellular zinc speciation drives cellular zinc uptake
Date
07/07/2022Author
Grant ID
BB/J006467/1
RPG-2017-214
BB/V014684/1
Metadata
Show full item recordAbstract
The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.
Citation
Coverdale , J P C , van den Berg , H A , Khazaipoul , S , Bridgewater , H E , Stewart , A J & Blindauer , C A 2022 , ' Albumin-mediated extracellular zinc speciation drives cellular zinc uptake ' , Chemical Communications , vol. 58 , no. 53 , pp. 7384-7387 . https://doi.org/10.1039/D2CC02278H
Publication
Chemical Communications
Status
Peer reviewed
ISSN
1359-7345Type
Journal article
Rights
Copyright © The Author(s). Open Access. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Description
This work was financially supported by the Leverhulme Trust (RPG-2017-214) and BBSRC (BB/J006467/1 and BB/V014684/1). We thank Prof. Andrew Riches (University of St. Andrews) for provision of materials, and Dr. Elizabeth Bolitho (University of Warwick) for assistance with cell culture experiments.Collections
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.