Albumin-mediated extracellular zinc speciation drives cellular zinc uptake
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The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.
Coverdale , J P C , van den Berg , H A , Khazaipoul , S , Bridgewater , H E , Stewart , A J & Blindauer , C A 2022 , ' Albumin-mediated extracellular zinc speciation drives cellular zinc uptake ' , Chemical Communications , vol. 58 , no. 53 , pp. 7384-7387 . https://doi.org/10.1039/D2CC02278H
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DescriptionThis work was financially supported by the Leverhulme Trust (RPG-2017-214) and BBSRC (BB/J006467/1 and BB/V014684/1). We thank Prof. Andrew Riches (University of St. Andrews) for provision of materials, and Dr. Elizabeth Bolitho (University of Warwick) for assistance with cell culture experiments.
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