Isothiourea-catalysed enantioselective radical conjugate addition under batch and flow conditions

del Río-Rodríguez, Roberto; Westwood, Matthew; Sicignano, Marina; Juhl, Martin; Fernández-Salas, Jose A.; Alemán, José; Smith, Andrew D.

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dc.contributor.author	del Río-Rodríguez, Roberto
dc.contributor.author	Westwood, Matthew
dc.contributor.author	Sicignano, Marina
dc.contributor.author	Juhl, Martin
dc.contributor.author	Fernández-Salas, Jose A.
dc.contributor.author	Alemán, José
dc.contributor.author	Smith, Andrew D.
dc.date.accessioned	2022-06-14T10:30:17Z
dc.date.available	2022-06-14T10:30:17Z
dc.date.issued	2022-07-04
dc.identifier.citation	del Río-Rodríguez , R , Westwood , M , Sicignano , M , Juhl , M , Fernández-Salas , J A , Alemán , J & Smith , A D 2022 , ' Isothiourea-catalysed enantioselective radical conjugate addition under batch and flow conditions ' , Chemical Communications , vol. 58 , no. 52 , pp. 7277-7280 . https://doi.org/10.1039/D2CC02432B	en
dc.identifier.issn	1359-7345
dc.identifier.other	PURE: 279714101
dc.identifier.other	PURE UUID: 98c6eded-9bc2-4ebc-8d3b-561e91e7df20
dc.identifier.other	ORCID: /0000-0002-2104-7313/work/113703528
dc.identifier.other	WOS: 000807559600001
dc.identifier.other	Scopus: 85131859758
dc.identifier.uri	http://hdl.handle.net/10023/25526
dc.description	Financial support was provided by the Spanish Government (RTI2018-095038-B-I00), “Comunidad de Madrid” for European Structural Funds (S2018/NMT-4367) and proyectos sinergicos I+D (Y2020/NMT-6469). J. A. F.-S. thanks the Spanish Government for a Ramón y Cajal contract. The research leading to these results has received funding from the EaSI-CAT centre for Doctoral Training (M.T.W) and Carlsberg Foundation (M.J.).	en
dc.description.abstract	The photocatalytic generation of α-amino radicals is combined with chiral isothiourea derived α,β-unsaturated acyl ammonium intermediates. The reaction proceeds via a [3+2] radical-polar crossover mechanism to generate γ-lactams in good yields and enantioselectivities. The enantioselective radical conjugate addition was carried out under batch and flow conditions.
dc.format.extent	4
dc.language.iso	eng
dc.relation.ispartof	Chemical Communications	en
dc.rights	Copyright © 2022 The Author(s). Open Access. This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.	en
dc.subject	QD Chemistry	en
dc.subject	DAS	en
dc.subject	MCC	en
dc.subject.lcc	QD	en
dc.title	Isothiourea-catalysed enantioselective radical conjugate addition under batch and flow conditions	en
dc.type	Journal article	en
dc.description.version	Publisher PDF	en
dc.contributor.institution	University of St Andrews. School of Chemistry	en
dc.identifier.doi	https://doi.org/10.1039/D2CC02432B
dc.description.status	Peer reviewed	en

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