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dc.contributor.authordel Río-Rodríguez, Roberto
dc.contributor.authorWestwood, Matthew
dc.contributor.authorSicignano, Marina
dc.contributor.authorJuhl, Martin
dc.contributor.authorFernández-Salas, Jose A.
dc.contributor.authorAlemán, José
dc.contributor.authorSmith, Andrew D.
dc.identifier.citationdel Río-Rodríguez , R , Westwood , M , Sicignano , M , Juhl , M , Fernández-Salas , J A , Alemán , J & Smith , A D 2022 , ' Isothiourea-catalysed enantioselective radical conjugate addition under batch and flow conditions ' , Chemical Communications , vol. 58 , no. 52 , pp. 7277-7280 .
dc.identifier.otherPURE: 279714101
dc.identifier.otherPURE UUID: 98c6eded-9bc2-4ebc-8d3b-561e91e7df20
dc.identifier.otherORCID: /0000-0002-2104-7313/work/113703528
dc.identifier.otherWOS: 000807559600001
dc.identifier.otherScopus: 85131859758
dc.descriptionFinancial support was provided by the Spanish Government (RTI2018-095038-B-I00), “Comunidad de Madrid” for European Structural Funds (S2018/NMT-4367) and proyectos sinergicos I+D (Y2020/NMT-6469). J. A. F.-S. thanks the Spanish Government for a Ramón y Cajal contract. The research leading to these results has received funding from the EaSI-CAT centre for Doctoral Training (M.T.W) and Carlsberg Foundation (M.J.).en
dc.description.abstractThe photocatalytic generation of α-amino radicals is combined with chiral isothiourea derived α,β-unsaturated acyl ammonium intermediates. The reaction proceeds via a [3+2] radical-polar crossover mechanism to generate γ-lactams in good yields and enantioselectivities. The enantioselective radical conjugate addition was carried out under batch and flow conditions.
dc.relation.ispartofChemical Communicationsen
dc.rightsCopyright © 2022 The Author(s). Open Access. This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.en
dc.subjectQD Chemistryen
dc.titleIsothiourea-catalysed enantioselective radical conjugate addition under batch and flow conditionsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.description.statusPeer revieweden

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