Isothiourea-catalysed enantioselective radical conjugate addition under batch and flow conditions
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The photocatalytic generation of α-amino radicals is combined with chiral isothiourea derived α,β-unsaturated acyl ammonium intermediates. The reaction proceeds via a [3+2] radical-polar crossover mechanism to generate γ-lactams in good yields and enantioselectivities. The enantioselective radical conjugate addition was carried out under batch and flow conditions.
del Río-Rodríguez , R , Westwood , M , Sicignano , M , Juhl , M , Fernández-Salas , J A , Alemán , J & Smith , A D 2022 , ' Isothiourea-catalysed enantioselective radical conjugate addition under batch and flow conditions ' , Chemical Communications , vol. Advance Article . https://doi.org/10.1039/D2CC02432B
Copyright © 2022 The Author(s). Open Access. This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.
DescriptionFinancial support was provided by the Spanish Government (RTI2018-095038-B-I00), “Comunidad de Madrid” for European Structural Funds (S2018/NMT-4367) and proyectos sinergicos I+D (Y2020/NMT-6469). J. A. F.-S. thanks the Spanish Government for a Ramón y Cajal contract. The research leading to these results has received funding from the EaSI-CAT centre for Doctoral Training (M.T.W) and Carlsberg Foundation (M.J.).
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