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dc.contributor.authorTitze, Vera M.
dc.contributor.authorCaixeiro , Soraya
dc.contributor.authorDi Falco, Andrea
dc.contributor.authorSchubert, Marcel
dc.contributor.authorGather, Malte C.
dc.date.accessioned2022-05-04T10:30:19Z
dc.date.available2022-05-04T10:30:19Z
dc.date.issued2022-03-16
dc.identifier277738376
dc.identifierdd263e08-a59b-40e0-95f5-827eb0d08528
dc.identifier85125369996
dc.identifier000776221600029
dc.identifier.citationTitze , V M , Caixeiro , S , Di Falco , A , Schubert , M & Gather , M C 2022 , ' Red-shifted excitation and two-photon pumping of biointegrated GaInP/AlGaInP quantum well microlasers ' , ACS Photonics , vol. 9 , no. 3 , pp. 952-960 . https://doi.org/10.1021/acsphotonics.1c01807en
dc.identifier.issn2330-4022
dc.identifier.otherORCID: /0000-0002-7338-8785/work/108508483
dc.identifier.otherORCID: /0000-0002-4857-5562/work/108508636
dc.identifier.otherORCID: /0000-0002-8739-4852/work/108508674
dc.identifier.otherORCID: /0000-0003-4605-957X/work/108508936
dc.identifier.otherORCID: /0000-0003-0724-7084/work/108508962
dc.identifier.urihttps://hdl.handle.net/10023/25277
dc.descriptionThis work received financial support from the Leverhulme Trust (RPG-2017-231), European Union’s Horizon 2020 Framework Programme (FP/2014-2020)/ERC grant agreement no. 640012 (ABLASE), EPSRC (EP/P030017/1), and the Humboldt Foundation (Alexander von Humboldt professorship). MS acknowledges funding by the Royal Society (Dorothy Hodgkin Fellowship, DH160102; Research Grant, RGF\R1\180070; Enhancement Award, RGF\EA\180051). ADF acknowledges support from European Research Council (ERC) under the European Union Horizon 2020 research and innovation program (Grant Agreement No. 819346).en
dc.description.abstractBiointegrated intracellular microlasers have emerged as an attractive and versatile tool in biophotonics. Different inorganic semiconductor materials have been used for the fabrication of such biocompatible microlasers, but often operate at visible wavelengths ill-suited for imaging through tissue. Here, we report on whispering gallery mode microdisk lasers made from a range of GaInP/AlGaInP multi-quantum well structures with compositions tailored to red-shifted excitation and emission. The selected semiconductor alloys show minimal toxicity and allow fabrication of lasers with stable single-mode emission in the NIR (675 – 720 nm) and sub-pJ thresholds. The microlasers operate in the first therapeutic window under direct excitation by a conventional diode laser and can also be pumped in the second therapeutic window using two-photon excitation at pulse energies compatible with standard multiphoton microscopy. Stable performance is observed under cell culturing conditions for five days without any device encapsulation. With their bio-optimized spectral characteristics, low lasing threshold and compatibility with two-photon pumping, AlGaInP-based microlasers are ideally suited for novel cell tagging and in vivo sensing applications.
dc.format.extent9
dc.format.extent4138213
dc.language.isoeng
dc.relation.ispartofACS Photonicsen
dc.subjectMicrolasersen
dc.subjectQuantum wellsen
dc.subjectIII-V semiconductorsen
dc.subjectCell trackingen
dc.subjectTwo-photon excitationen
dc.subjectQC Physicsen
dc.subjectDASen
dc.subject.lccQCen
dc.titleRed-shifted excitation and two-photon pumping of biointegrated GaInP/AlGaInP quantum well microlasersen
dc.typeJournal articleen
dc.contributor.sponsorEuropean Research Councilen
dc.contributor.sponsorEPSRCen
dc.contributor.sponsorThe Royal Societyen
dc.contributor.sponsorEuropean Research Councilen
dc.contributor.sponsorThe Royal Societyen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.contributor.institutionUniversity of St Andrews. Centre for Biophotonicsen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doi10.1021/acsphotonics.1c01807
dc.description.statusPeer revieweden
dc.identifier.grantnumber640012en
dc.identifier.grantnumberEP/P030017/1en
dc.identifier.grantnumberRGF/R1/180070en
dc.identifier.grantnumber819346en
dc.identifier.grantnumberRGF/EA/180051en


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