Synthesis of 2-BMIDA indoles via heteroannulation : applications in drug scaffold and natural product synthesis

Bell, George; Fyfe, James W. B.; Israel, Eva M.; Slawin, Alexandra M. Z.; Campbell, Matthew; Watson, Allan J. B.

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dc.contributor.author	Bell, George
dc.contributor.author	Fyfe, James W. B.
dc.contributor.author	Israel, Eva M.
dc.contributor.author	Slawin, Alexandra M. Z.
dc.contributor.author	Campbell, Matthew
dc.contributor.author	Watson, Allan J. B.
dc.date.accessioned	2022-04-15T14:30:46Z
dc.date.available	2022-04-15T14:30:46Z
dc.date.issued	2022-04-15
dc.identifier.citation	Bell , G , Fyfe , J W B , Israel , E M , Slawin , A M Z , Campbell , M & Watson , A J B 2022 , ' Synthesis of 2-BMIDA indoles via heteroannulation : applications in drug scaffold and natural product synthesis ' , Organic Letters , vol. Articles ASAP . https://doi.org/10.1021/acs.orglett.2c00959	en
dc.identifier.issn	1523-7060
dc.identifier.other	PURE: 278930737
dc.identifier.other	PURE UUID: 183f77fc-eae0-4d0c-b04d-32fee4531509
dc.identifier.other	ORCID: /0000-0002-9527-6418/work/111547256
dc.identifier.other	ORCID: /0000-0002-1582-4286/work/111547566
dc.identifier.other	WOS: 000793795000013
dc.identifier.other	Scopus: 85128648550
dc.identifier.uri	https://hdl.handle.net/10023/25192
dc.description	G.E.B. thanks the EPSRC and GSK for a PhD studentship. J.W.B.F. thanks the Leverhulme Trust for postdoctoral funding (RPG-2018-362).	en
dc.description.abstract	A Pd-catalyzed heteroannulation approach for the synthesis of C2 borylated indoles is reported. The process allows access to highly functionalized 2-borylated indole scaffolds with complete control of regioselectivity. The utility of the process is demonstrated in the synthesis of borylated sulfa drugs and in the concise synthesis of the Aspidosperma alkaloid Goniomitine.
dc.format.extent	4
dc.language.iso	eng
dc.relation.ispartof	Organic Letters	en
dc.rights	© 2022 The Authors. Published by American Chemical Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.	en
dc.subject	QD Chemistry	en
dc.subject	DAS	en
dc.subject.lcc	QD	en
dc.title	Synthesis of 2-BMIDA indoles via heteroannulation : applications in drug scaffold and natural product synthesis	en
dc.type	Journal article	en
dc.description.version	Publisher PDF	en
dc.contributor.institution	University of St Andrews. School of Chemistry	en
dc.contributor.institution	University of St Andrews. EaSTCHEM	en
dc.contributor.institution	University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis	en
dc.identifier.doi	https://doi.org/10.1021/acs.orglett.2c00959
dc.description.status	Peer reviewed	en

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