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Synthesis of 2-BMIDA indoles via heteroannulation : applications in drug scaffold and natural product synthesis

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dc.contributor.authorBell, George
dc.contributor.authorFyfe, James W. B.
dc.contributor.authorIsrael, Eva M.
dc.contributor.authorSlawin, Alexandra M. Z.
dc.contributor.authorCampbell, Matthew
dc.contributor.authorWatson, Allan J. B.
dc.date.accessioned2022-04-15T14:30:46Z
dc.date.available2022-04-15T14:30:46Z
dc.date.issued2022-04-15
dc.identifier278930737
dc.identifier183f77fc-eae0-4d0c-b04d-32fee4531509
dc.identifier000793795000013
dc.identifier85128648550
dc.identifier.citationBell , G , Fyfe , J W B , Israel , E M , Slawin , A M Z , Campbell , M & Watson , A J B 2022 , ' Synthesis of 2-BMIDA indoles via heteroannulation : applications in drug scaffold and natural product synthesis ' , Organic Letters , vol. Articles ASAP . https://doi.org/10.1021/acs.orglett.2c00959en
dc.identifier.issn1523-7060
dc.identifier.otherORCID: /0000-0002-9527-6418/work/111547256
dc.identifier.otherORCID: /0000-0002-1582-4286/work/111547566
dc.identifier.urihttps://hdl.handle.net/10023/25192
dc.descriptionG.E.B. thanks the EPSRC and GSK for a PhD studentship. J.W.B.F. thanks the Leverhulme Trust for postdoctoral funding (RPG-2018-362).en
dc.description.abstractA Pd-catalyzed heteroannulation approach for the synthesis of C2 borylated indoles is reported. The process allows access to highly functionalized 2-borylated indole scaffolds with complete control of regioselectivity. The utility of the process is demonstrated in the synthesis of borylated sulfa drugs and in the concise synthesis of the Aspidosperma alkaloid Goniomitine.
dc.format.extent4
dc.format.extent975841
dc.language.isoeng
dc.relation.ispartofOrganic Lettersen
dc.subjectQD Chemistryen
dc.subjectDASen
dc.subject.lccQDen
dc.titleSynthesis of 2-BMIDA indoles via heteroannulation : applications in drug scaffold and natural product synthesisen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.identifier.doihttps://doi.org/10.1021/acs.orglett.2c00959
dc.description.statusPeer revieweden


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