Synthesis of 2-BMIDA indoles via heteroannulation : applications in drug scaffold and natural product synthesis
Date
15/04/2022Metadata
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Abstract
A Pd-catalyzed heteroannulation approach for the synthesis of C2 borylated indoles is reported. The process allows access to highly functionalized 2-borylated indole scaffolds with complete control of regioselectivity. The utility of the process is demonstrated in the synthesis of borylated sulfa drugs and in the concise synthesis of the Aspidosperma alkaloid Goniomitine.
Citation
Bell , G , Fyfe , J W B , Israel , E M , Slawin , A M Z , Campbell , M & Watson , A J B 2022 , ' Synthesis of 2-BMIDA indoles via heteroannulation : applications in drug scaffold and natural product synthesis ' , Organic Letters , vol. Articles ASAP . https://doi.org/10.1021/acs.orglett.2c00959
Publication
Organic Letters
Status
Peer reviewed
ISSN
1523-7060Type
Journal article
Rights
© 2022 The Authors. Published by American Chemical Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Description
G.E.B. thanks the EPSRC and GSK for a PhD studentship. J.W.B.F. thanks the Leverhulme Trust for postdoctoral funding (RPG-2018-362).Collections
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