Files in this item
Association between chronic psychoactive substances use and systemic inflammation : a systematic review and meta-analysis
Item metadata
dc.contributor.author | Doggui, Radhouene | |
dc.contributor.author | Elsawy, Wafaa | |
dc.contributor.author | Conti, Aldo Alberto | |
dc.contributor.author | Baldacchino, Alexander Mario | |
dc.date.accessioned | 2022-04-14T16:32:51Z | |
dc.date.available | 2022-04-14T16:32:51Z | |
dc.date.issued | 2021-06 | |
dc.identifier | 273035916 | |
dc.identifier | 8b9161bf-5273-49fa-9efe-6ced61b57970 | |
dc.identifier | 85101743404 | |
dc.identifier | 000646733700002 | |
dc.identifier.citation | Doggui , R , Elsawy , W , Conti , A A & Baldacchino , A M 2021 , ' Association between chronic psychoactive substances use and systemic inflammation : a systematic review and meta-analysis ' , Neuroscience and Biobehavioral Reviews , vol. 125 , pp. 208-220 . https://doi.org/10.1016/j.neubiorev.2021.02.031 | en |
dc.identifier.issn | 0149-7634 | |
dc.identifier.other | ORCID: /0000-0002-0467-9431/work/90567967 | |
dc.identifier.other | ORCID: /0000-0002-5388-7376/work/90568135 | |
dc.identifier.uri | https://hdl.handle.net/10023/25187 | |
dc.description.abstract | This systematic review and meta-analysis assess the change in inflammation biomarkers level among chronic psychoactive substance users. To meet the required inclusion criteria, all studies had to describe human participants with an age ≥18y., experiencing chronic psychostimulant (nicotine, amphetamine, cocaine), sedative (benzodiazepine, opioids) and/or cannabinoid use. The comparison group was defined as healthy participants. Studies where included if they reported at least one of the pro/inflammatory biomarkers. Study bias was examined by Funnel plots and heterogeneity by computing the I2 statistics. Only 21 eligible studies were selected based on 26216 study participants. A small and significant effect size of 0.18mg/L (95% CI:0.10-0.27) was detected in favor of chronic smokers (z=4.33;P<0.0001). There was evidence of publication bias for studies measuring IL-6 and IL-10 association with cocaine and IL-6 in association with cannabis. In summary, except for chronic tobacco users, there was no evidence of association between other chronic substances abuse and inflammatory levels. More studies are needed to inform policy and decision makers about the utility of anti-inflammatory based targeted intervention programs. | |
dc.format.extent | 1569936 | |
dc.language.iso | eng | |
dc.relation.ispartof | Neuroscience and Biobehavioral Reviews | en |
dc.subject | Alcohol | en |
dc.subject | Cytokines | en |
dc.subject | Opioids | en |
dc.subject | Nicotine | en |
dc.subject | Stimulants | en |
dc.subject | Bioinflammatory markers | en |
dc.subject | Chronic psychoactive substance use | en |
dc.subject | QH301 Biology | en |
dc.subject | RA0421 Public health. Hygiene. Preventive Medicine | en |
dc.subject | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | en |
dc.subject | T-NDAS | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | QH301 | en |
dc.subject.lcc | RA0421 | en |
dc.subject.lcc | RC0321 | en |
dc.title | Association between chronic psychoactive substances use and systemic inflammation : a systematic review and meta-analysis | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. Population and Behavioural Science Division | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Centre for Minorities Research (CMR) | en |
dc.identifier.doi | 10.1016/j.neubiorev.2021.02.031 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2022-02-24 |
This item appears in the following Collection(s)
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.