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dc.contributor.authorDoggui, Radhouene
dc.contributor.authorElsawy, Wafaa
dc.contributor.authorConti, Aldo Alberto
dc.contributor.authorBaldacchino, Alexander Mario
dc.date.accessioned2022-04-14T16:32:51Z
dc.date.available2022-04-14T16:32:51Z
dc.date.issued2021-06
dc.identifier273035916
dc.identifier8b9161bf-5273-49fa-9efe-6ced61b57970
dc.identifier85101743404
dc.identifier000646733700002
dc.identifier.citationDoggui , R , Elsawy , W , Conti , A A & Baldacchino , A M 2021 , ' Association between chronic psychoactive substances use and systemic inflammation : a systematic review and meta-analysis ' , Neuroscience and Biobehavioral Reviews , vol. 125 , pp. 208-220 . https://doi.org/10.1016/j.neubiorev.2021.02.031en
dc.identifier.issn0149-7634
dc.identifier.otherORCID: /0000-0002-0467-9431/work/90567967
dc.identifier.otherORCID: /0000-0002-5388-7376/work/90568135
dc.identifier.urihttps://hdl.handle.net/10023/25187
dc.description.abstractThis systematic review and meta-analysis assess the change in inflammation biomarkers level among chronic psychoactive substance users. To meet the required inclusion criteria, all studies had to describe human participants with an age ≥18y., experiencing chronic psychostimulant (nicotine, amphetamine, cocaine), sedative (benzodiazepine, opioids) and/or cannabinoid use. The comparison group was defined as healthy participants. Studies where included if they reported at least one of the pro/inflammatory biomarkers. Study bias was examined by Funnel plots and heterogeneity by computing the I2 statistics. Only 21 eligible studies were selected based on 26216 study participants. A small and significant effect size of 0.18mg/L (95% CI:0.10-0.27) was detected in favor of chronic smokers (z=4.33;P<0.0001). There was evidence of publication bias for studies measuring IL-6 and IL-10 association with cocaine and IL-6 in association with cannabis. In summary, except for chronic tobacco users, there was no evidence of association between other chronic substances abuse and inflammatory levels. More studies are needed to inform policy and decision makers about the utility of anti-inflammatory based targeted intervention programs.
dc.format.extent1569936
dc.language.isoeng
dc.relation.ispartofNeuroscience and Biobehavioral Reviewsen
dc.subjectAlcoholen
dc.subjectCytokinesen
dc.subjectOpioidsen
dc.subjectNicotineen
dc.subjectStimulantsen
dc.subjectBioinflammatory markersen
dc.subjectChronic psychoactive substance useen
dc.subjectQH301 Biologyen
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectT-NDASen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccQH301en
dc.subject.lccRA0421en
dc.subject.lccRC0321en
dc.titleAssociation between chronic psychoactive substances use and systemic inflammation : a systematic review and meta-analysisen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. Population and Behavioural Science Divisionen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Centre for Minorities Research (CMR)en
dc.identifier.doi10.1016/j.neubiorev.2021.02.031
dc.description.statusPeer revieweden
dc.date.embargoedUntil2022-02-24


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