Association between chronic psychoactive substances use and systemic inflammation : a systematic review and meta-analysis
MetadataShow full item record
This systematic review and meta-analysis assess the change in inflammation biomarkers level among chronic psychoactive substance users. To meet the required inclusion criteria, all studies had to describe human participants with an age ≥18y., experiencing chronic psychostimulant (nicotine, amphetamine, cocaine), sedative (benzodiazepine, opioids) and/or cannabinoid use. The comparison group was defined as healthy participants. Studies where included if they reported at least one of the pro/inflammatory biomarkers. Study bias was examined by Funnel plots and heterogeneity by computing the I2 statistics. Only 21 eligible studies were selected based on 26216 study participants. A small and significant effect size of 0.18mg/L (95% CI:0.10-0.27) was detected in favor of chronic smokers (z=4.33;P<0.0001). There was evidence of publication bias for studies measuring IL-6 and IL-10 association with cocaine and IL-6 in association with cannabis. In summary, except for chronic tobacco users, there was no evidence of association between other chronic substances abuse and inflammatory levels. More studies are needed to inform policy and decision makers about the utility of anti-inflammatory based targeted intervention programs.
Doggui , R , Elsawy , W , Conti , A A & Baldacchino , A M 2021 , ' Association between chronic psychoactive substances use and systemic inflammation : a systematic review and meta-analysis ' , Neuroscience and Biobehavioral Reviews , vol. 125 , pp. 208-220 . https://doi.org/10.1016/j.neubiorev.2021.02.031
Neuroscience and Biobehavioral Reviews
Copyright © 2021 Elsevier Ltd. All rights reserved. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.neubiorev.2021.02.031.
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.