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dc.contributor.authorTolomeo, Serenella
dc.contributor.authorBaldacchino, Alexander Mario
dc.contributor.authorVolkow, Nora
dc.contributor.authorSteele, Douglas
dc.date.accessioned2022-02-28T15:30:11Z
dc.date.available2022-02-28T15:30:11Z
dc.date.issued2022-02-26
dc.identifier277181732
dc.identifierde5c0064-9b1f-43c0-b051-1c78cb3462ab
dc.identifier85125541682
dc.identifier85125541682
dc.identifier35217657
dc.identifier000761940400003
dc.identifier.citationTolomeo , S , Baldacchino , A M , Volkow , N & Steele , D 2022 , ' Protracted abstinence in males with an opioid use disorder : partial recovery of nucleus accumbens function ' , Translational Psychiatry , vol. 12 , 81 . https://doi.org/10.1038/s41398-022-01813-4en
dc.identifier.issn2158-3188
dc.identifier.otherORCID: /0000-0002-5388-7376/work/109316034
dc.identifier.urihttps://hdl.handle.net/10023/24961
dc.description.abstractOpioid use disorder (OUD) affects more than 27 million people globally accounting for more than 300,000 deaths annually. Protracted abstinence among individuals with OUD is rare due to a high relapse rate among those not receiving medications for OUD. Extensive preclinical studies form the basis of the allostasis theory, which proposes long lasting functional brain abnormalities that persist after opioid withdrawal and contribute to relapse. Few studies have tested the allostasis theory in humans using neuroimaging. Here we used fMRI and an instrumental learning task to test allostasis theory predictions (ATP) of functional abnormalities in both positive valence (PVS) and negative valence (NVS) accumbens systems in OUD patients with protracted abstinence (n=15), comparing them with OUD patients receiving methadone treatment (MT) (n=33), and with healthy controls (n=23). As hypothesized, protracted abstinence OUD patients showed incomplete recovery of nucleus accumbens function, as evidenced by blunted response to aversive events (NVS) during negative reinforcement, as observed in MT patients. In contrast, their accumbens response to rewarding events (PVS) during positive reinforcement was similar to that of controls and different to that in MT patients whose response was blunted. Protracted abstinence OUD patients also showed improvements in depression symptoms compared to MT patients. Residual depressive symptoms and pre-MT intravenous drug measures were associated with worse accumbens function in protracted abstinence. These results support the ATP of long lasting dysfunction of NVS after withdrawal and show preliminary evidence of recovery of PVS function with protracted withdrawal. Therapeutic strategies that target NVS may facilitate recovery.
dc.format.extent7
dc.format.extent1473872
dc.language.isoeng
dc.relation.ispartofTranslational Psychiatryen
dc.subjectAllostasis theoryen
dc.subjectAbstinenceen
dc.subjectfMRIen
dc.subjectTranslational researchen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectRM Therapeutics. Pharmacologyen
dc.subjectPsychiatry and Mental healthen
dc.subjectCellular and Molecular Neuroscienceen
dc.subjectBiological Psychiatryen
dc.subjectNDASen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccRC0321en
dc.subject.lccRMen
dc.titleProtracted abstinence in males with an opioid use disorder : partial recovery of nucleus accumbens functionen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Centre for Minorities Research (CMR)en
dc.contributor.institutionUniversity of St Andrews. Population and Behavioural Science Divisionen
dc.identifier.doi10.1038/s41398-022-01813-4
dc.description.statusPeer revieweden


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