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dc.contributor.authorFeeney, Katherine Martha
dc.contributor.authorParish, Joanna Louise
dc.identifier.citationFeeney , K M & Parish , J L 2009 , ' Targeting mitotic chromosomes : a conserved mechanism to ensure viral genome persistence ' , Proceedings of the Royal Society B: Biological Sciences , vol. 276 , no. 1662 , pp. 1535-1544 .
dc.identifier.otherPURE: 427169
dc.identifier.otherPURE UUID: 7918890c-11d9-4bb4-bcb5-9f15562b8151
dc.identifier.otherWOS: 000264445000001
dc.identifier.otherScopus: 66349129914
dc.description.abstractViruses that maintain their genomes as extrachromosomal circular DNA molecules and establish infection in actively dividing cells must ensure retention of their genomes within the nuclear envelope in order to prevent genome loss. The loss of nuclear membrane integrity during mitosis dictates that paired host cell chromosomes are captured and organized by the mitotic spindle apparatus before segregation to daughter cells. This prevents inaccurate chromosomal segregation and loss of genetic material. A similar mechanism may also exist for the nuclear retention of extrachromosomal viral genomes or episomes during mitosis, particularly for genomes maintained at a low copy number in latent infections. It has been heavily debated whether such a mechanism exists and to what extent this mechanism is conserved among diverse viruses. Research over the last two decades has provided a wealth of information regarding the mechanisms by which specific tumour viruses evade mitotic and DNA damage checkpoints. Here, we discuss the similarities and differences in how specific viruses tether episomal genomes to host cell chromosomes during mitosis to ensure long-term persistence.
dc.relation.ispartofProceedings of the Royal Society B: Biological Sciencesen
dc.rightsCopyright © 2009 The Royal Society This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectViral persistenceen
dc.subjectDNA tumour virusen
dc.subjectSarcoma-associated herpesvirusen
dc.subjectPapillomavirus E2 proteinen
dc.subjectNuclear antigen lanaen
dc.subjectLatent DNA-replicationen
dc.subjectTranscriptional activationen
dc.subjectTerminal repeatsen
dc.subjectMurine gammaherpesvirus-68en
dc.subjectQH426 Geneticsen
dc.titleTargeting mitotic chromosomes : a conserved mechanism to ensure viral genome persistenceen
dc.typeJournal articleen
dc.contributor.sponsorThe Royal Societyen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.description.statusPeer revieweden

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