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FeenayParish2009ProcRSocB276TargetingMitotic.pdf342.12 kBAdobe PDFView/Open
Title: Targeting mitotic chromosomes : a conserved mechanism to ensure viral genome persistence
Authors: Feeney, Katherine Martha
Parish, Joanna Louise
Keywords: Viral persistence
DNA tumour virus
Sarcoma-associated herpesvirus
Papillomavirus E2 protein
Nuclear antigen lana
Latent DNA-replication
Transcriptional activation
Terminal repeats
Murine gammaherpesvirus-68
QH426 Genetics
Issue Date: 7-May-2009
Citation: Feeney , K M & Parish , J L 2009 , ' Targeting mitotic chromosomes : a conserved mechanism to ensure viral genome persistence ' Proceedings of the Royal Society B: Biological Sciences , vol 276 , no. 1662 , pp. 1535-1544 . , 10.1098/rspb.2008.1642
Abstract: Viruses that maintain their genomes as extrachromosomal circular DNA molecules and establish infection in actively dividing cells must ensure retention of their genomes within the nuclear envelope in order to prevent genome loss. The loss of nuclear membrane integrity during mitosis dictates that paired host cell chromosomes are captured and organized by the mitotic spindle apparatus before segregation to daughter cells. This prevents inaccurate chromosomal segregation and loss of genetic material. A similar mechanism may also exist for the nuclear retention of extrachromosomal viral genomes or episomes during mitosis, particularly for genomes maintained at a low copy number in latent infections. It has been heavily debated whether such a mechanism exists and to what extent this mechanism is conserved among diverse viruses. Research over the last two decades has provided a wealth of information regarding the mechanisms by which specific tumour viruses evade mitotic and DNA damage checkpoints. Here, we discuss the similarities and differences in how specific viruses tether episomal genomes to host cell chromosomes during mitosis to ensure long-term persistence.
Version: Publisher PDF
Status: Peer reviewed
ISSN: 0962-8452
Type: Journal article
Rights: Copyright © 2009 The Royal Society This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:University of St Andrews Research
Medicine Research
Biomedical Sciences Research Complex (BSRC) Research

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